Beneficial Effect of Traditional Chinese Medicinal Formula Danggui-Shaoyao-San on Advanced Glycation End-Product-Mediated Renal Injury in Streptozotocin-Diabetic Rats

Table 2

Changes of the renal function-related parameters in STZ-diabetic rats receiving DSS treatment.

Groups	Period (week)	Serum Cr (mg dL^−1)	BUN (mg dL^−1)	Urine volume (mL^−1)	Ccr; (ml min^−1 per kg)	UAER (𝜇g 24 h^−1)
Nondiabetic rats
Vehicle	0	0.33 ± 0.09^c	17.3 ± 2.6^d	10.9 ± 2.8^d	0.65 ± 0.15^d	2.8 ± 0.2^d
	4th	0.34 ± 0.12^c	17.8 ± 3.1^d	11.4 ± 3.2^d	0.62 ± 0.17^d	2.6 ± 0.4^d
	8th	0.34 ± 0.09^c	18.4 ± 2.8^d	11.7 ± 2.9^d	0.64 ± 0.14^d	2.7 ± 0.2^d
	12th	0.35 ± 0.06^c	18.2 ± 3.4^d	12.1 ± 3.5^d	0.68 ± 0.13^d	2.9 ± 0.3^d
STZ-diabetic rats
Vehicle	0	0.51 ± 0.06^a	28.4 ± 3.3^b	25.4 ± 3.7^b	1.56 ± 0.21^b	15.4 ± 2.1^b
	4th	0.53 ± 0.08^a	29.7 ± 2.7^b	26.9 ± 2.5^b	1.64 ± 0.18^b	16.3 ± 1.9^b
	8th	0.58 ± 0.07^a	31.6 ± 3.6^b	30.2 ± 2.8^b	1.73 ± 0.15^b	17.5 ± 2.6^b
	12th	0.64 ± 0.08^a	33.6 ± 2.9^b	33.6 ± 3.2^b	1.80 ± 0.19^b	19.4 ± 3.2^b
DSS (2.8 g kg^−1 per day)	0	0.50 ± 0.06^a	28.6 ± 2.8^b	25.3 ± 3.2^b	1.55 ± 0.23^b	14.9 ± 2.6^b
	4th	0.50 ± 0.10^a	27.8 ± 3.2^b	24.8 ± 3.4^b	1.58 ± 0.16^b	13.7 ± 2.5^b
	8th	0.51 ± 0.12^a	28.2 ± 3.4^b	26.2 ± 2.9^b	1.52 ± 0.18^b	14.8 ± 2.2^b
	12th	0.54 ± 0.09^a	27.2 ± 3.5^b	27.8 ± 2.8^b	1.43 ± 0.21^b	15.1 ± 3.1^b

Values (mean ± SD) were obtained for each group of 8 animals. ^a𝑃<0.05 and ^b𝑃<0.01 compared to the values of vehicle-treated nondiabetic rats at the corresponding time, respectively. ^c𝑃<0.05 and ^d𝑃<0.01 compared to the values of vehicle-treated STZ-diabetic rats at the corresponding time, respectively.