Beneficial Effect of Traditional Chinese Medicinal Formula Danggui-Shaoyao-San on Advanced Glycation End-Product-Mediated Renal Injury in Streptozotocin-Diabetic Rats

Table 4

Renal levels of AGEs, CML, lipid peroxidation products, and antioxidant enzyme activity in STZ-diabetic rats receiving 12 weeks of DSS treatment.

Groups	AGEs (AU)	CML (ng mg^−1)	Lipid peroxidation products (nmol mg^−1)	SOD (U mg^−1)	GSH-Px (U mg^−1)
Nondiabetic rats
Vehicle	3.1 ± 0.2^d	20.2 ± 4.3^d	6.4 ± 0.6^d	12.3 ± 0.8^d	2.8 ± 0.4^c
STZ-diabetic rats
Vehicle	6.8 ± 0.3^b	43.3 ± 5.6^b	14.8 ± 1.2^b	6.7 ± 0.6^b	1.5 ± 0.2^a
DSS (2.8 g kg^−1 per day)	4.3 ± 0.2^a, c	30.4 ± 3.7^a, c	10.3 ± 0.7^a, c	10.1 ± 0.5^a, c	2.3 ± 0.2^c

Values (mean ± SD) were obtained for each group of 7 animals. ^a𝑃<0.05 and ^b𝑃<0.01 compared to the values of vehicle-treated nondiabetic rats, respectively. ^c𝑃<0.05 and ^d𝑃<0.01 compared to the values of vehicle-treated STZ-diabetic rats, respectively.