Isolation of Antidiabetic Principle from Fruit Rinds of Punica granatum

Table 4

Effect of single-dose oral administration of MEPG and VAD on blood glucose levels in alloxan-induced diabetic rats.

Group	Treatment	Blood glucose (mg/dL)
		0 hour	1 hour	2 hours	4 hours
G-I	Normal control	91.23±5.2	92.45±2.8	92.15±4.5	91.54±3.1
G-II	Vehicle control (3% Tween 80) 10 mL/kg, p.o.	272.84±3.9^#	274.41±5.1^#	277.65±5.1^#	268.94±4.6^#
G-III	Glibenclamide-10 mg/kg, p.o.	271.94±4.8	234.15±5.3	197.14±6.2^∗	164.85±6.5^∗
G-IV	MEPG-200 mg/kg, p.o.	268.51±6.2	271.15±4.8	255.41±7.9	264.12±6.1
G-V	MEPG-400 mg/kg, p.o.	272.84±5.2	269.64±6.5	242.12±4.8^∗	235.15±5.8^∗
G-VI	VAD-10 mg/kg, p.o.	259.87±5.5	265.32±7.3	264.85±3.7	261.25±7.3
G-VII	VAD-25 mg/kg, p.o.	264.51±7.1	261.25±3.5^∗	258.65±5.7^∗	256.52±4.9^∗
G-VIII	VAD-50 mg/kg, p.o.	274.56±4.5	241.85±6.1^∗	220.12±6.7^∗	198.56±5.3^∗

All the values are expressed as mean ± SEM, ^#𝑃<0.05 compared to normal control, and ^∗𝑃<0.05 compared to vehicle control (3% Tween 80).