Research Article

Evidence for Inhibitory Effects of Flupirtine, a Centrally Acting Analgesic, on Delayed Rectifier K+ Currents in Motor Neuron-Like Cells

Figure 4

Effect of Flu on steady-state inactivation of in NSC-34 cells. (a) Superimposed current traces obtained in the absence (upper) and presence (lower) of 3  M Flu. The conditioning voltage pulses with a duration of 10 sec to various membrane potentials. The voltage protocol used is shown in the uppermost part. (b) Steady-state inactivation of obtained in the absence (■) and presence (□) of 3  M Flu (mean ± SEM; –11 for each point).
148403.fig.004a
(a)
148403.fig.004b
(b)