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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 150458, 8 pages
Research Article

Protective Role of Ficus carica Stem Extract against Hepatic Oxidative Damage Induced by Methanol in Male Wistar Rats

1Animal Ecophysiology Laboratory, Sciences Faculty of Sfax 3038, Tunisia
2Department of life Sciences, Sciences Faculty of Sfax, BP 1171, Sfax 3000, Tunisia

Received 17 May 2011; Revised 11 August 2011; Accepted 25 August 2011

Academic Editor: S. Nagini

Copyright © 2012 Mongi Saoudi and Abdelfattah El Feki. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study was aimed to investigate the antioxidant activity of Ficus carica stem extract (FE) in methanol-induced hepatotoxicity in male Wistar rats. The rats were divided into two batches: 16 control rats (C) drinking tap water and 16 treated rats drinking Ficus carica stem extract for six weeks. Then, each group was divided into two subgroups, and one of them was intraperitoneally injected (i.p.) daily methanol at a dose of 2.37 g/kg body weight i.p. for 30 days, for four weeks. The results showed that FE was found to contain large amounts of polyphenols and carotenoids. The treatment with methanol exhibited a significant increase of serum hepatic biochemical parameters (ALT, AST, ALP, and LDH) and hepatic lipid peroxidation. Hepatic antioxidant enzymes, namely, SOD, CAT, and GSH-Px, were significantly decreased in methanol-treated animals. FE treatment prior to methanol intoxication has significant role in protecting animals from methanol-induced hepatic oxidative damage.