Effects of Vitamin D Supplementation during the Induction and Progression of Osteoarthritis in a Rat Model

Figure 1

Experimental groups. A schematic example of the 20-day induction group and the 40-day progression group of rats with OA with or without supplementation is shown. The same scheme was applied for the other induction (3 and 10 days) and progression (20 and 40 days) groups. Vitamin D (4 IU/kg/d) was administrated orally with an esophagogastric cannula 14 HALO. The arrow indicates the group without vitamin supplementation (nV); the pointed arrow indicates the supplementation with vitamin D (sV). Each group was conformed by 10 rats, and every experiment was performed at least by triplicate.