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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 161062, 7 pages
http://dx.doi.org/10.1155/2012/161062
Research Article

Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells

1Nursing Department, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China
2National Population and Family Planning Key Laboratory of Contraceptives Drugs & Devices, Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China
3Pharmacy College, Jinan University, Guangzhou 510632, China
4Department of Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian 116021, China
5Department of Oncology, The Fifth Hospital of Dalian, Dalian 116021, China

Received 12 March 2012; Revised 26 April 2012; Accepted 26 April 2012

Academic Editor: José Luis Ríos

Copyright © 2012 Hao-Jie Pu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study was conducted to investigate the relationship between the anti-stress and hepato-protective effects of Schisandra Lignans Extract (SLE) on stress-induced liver damage. Seven weeks old male mice were fixed in a restraint tube for 18 h to induce liver damage. SLE was orally administered to animals for 5 days at dosages of 100 and 200 mg/kg/day before exposed to restraint stress. Oral administration of SLE significantly reduced restraint-induced liver damage in experimental animal. SLE was further found to significantly alleviate the provocation of corticosterone in stressed mice. SLE also significantly decreased oxidative damage and increased anti-oxidative capability of liver cells by preventing the over production and accumulation of free radicals. In conclusion, the protective effects of SLE on stress-induced liver damage were confirmed, and the correlation between hepatoprotective and anti-stress effects of schisandra lignans was possible related to its alleviation on the malignant effects of stressors for bio-homeostasis, such as balance of oxidation and reduction in cells.