Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy

Table 1

Effects of trigonelline on serum lipid parameters and body weight gain in diabetic rats.

Group	HbA1c (%)	Serum insulin (mU/L)	Insulin sensitivity index	Triglyceride (mmol/L)	Total cholesterol (mmol/L)	Weight gain (g)
Control	37.41 ± 8.53	33.24 ± 7.59	−2.31 ± 0.11	1.76 ± 0.24	0.76 ± 0.13	253.7 ± 18.0
Diabetes	59.44 ± 10.12*	47.16 ± 7.60*	−3.09 ± 0.06*	2.42 ± 0.46*	2.14 ± 0.18*	137.3 ± 7.6*
Diabetes + trigonelline	39.50 ± 10.75^##	36.80 ± 8.13^##	−2.38 ± 0.12^##	1.85 ± 0.21^##	0.79 ± 0.13^##	103.0 ± 4.3^##
Diabetes + sitagliptin	37.69 ± 7.81^##	45.79 ± 8.01	−2.46 ± 0.11	2.56 ± 0.51	2.18 ± 0.24	139.2 ± 12.3^#

Data are given as mean ± SD, 𝑛=10. *P < 0.01, compared with control rats; ^#P < 0.05, ^##P < 0.01, compared with diabetes rats.