Research Article
Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy
Table 2
Effects of trigonelline on motor and sensory nerve conduction velocity and tail flick latency in diabetic rats.
| Group | Motor nerve conduction velocity (m/s) | Sensory nerve conduction velocity (m/s) | Tail flick latency in cold immersion (s) | Tail flick latency in hot immersion (s) |
| Control | 55.34 ± 5.92 | 57.61 ± 6.85 | 14.5 ± 1.0 | 14.2 ± 0.9 | Diabetes | 35.04 ± 4.36* | 40.17 ± 4.03* | 5.2 ± 1.0* | 6.3 ± 0.7* | Diabetes + trigonelline | 49.74 ± 5.05## | 51.76 ± 4.82## | 12.4 ± 1.1## | 12.0 ± 1.3## | Diabetes + sitagliptin | 41.05 ± 5.27# | 47.68 ± 3.38## | 10.8 ± 0.8## | 10.7 ± 1.0## |
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Data are given as mean ± SD, n = 10. *P < 0.01, compared with control rats; #P < 0.05, ##P < 0.01, compared with diabetes rats.
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