Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula

Table 3

Effect of DSS treatment on brain monoamine neurotransmitter levels in CUS-treated mice.

Treatment	5-HT (ng/g)	NA (ng/g)	DA (ng/g)
Control	1016.2 ± 43.1	1433.5 ± 66.7	1444.4 ± 59.8
CUS + vehicle	713.2 ± 18.4^##	1012.2 ± 34.6^##	1254.8 ± 38.6^#
CUS + DSS-L	779.0 ± 47.9	1002.7 ± 33.4	1369.8 ± 19.1
CUS + DSS-H	831.0 ± 27.4	1181.8 ± 27.2*	1445.1 ± 56.6*

Brain monoamine neurotransmitter levels were obtained by using HPLC coupled with electrochemical detection method. Values given are the mean ± SEMs (𝑛=8).
^#𝑃<0.05; ^##𝑃<0.01 as compared with the nonstressed control; *𝑃<0.05 as compared with the CUS-treated control.