Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 178178, 13 pages
http://dx.doi.org/10.1155/2012/178178
Research Article

Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant

1School of Pharmacy, China Medical University, Taichung 404, Taiwan
2Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan
3Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan
4Department of Pharmacy, Da Chien General Hospital, Miaoli 360, Taiwan
5Department of Radiation Oncology, Chi Mei Medical Center, Tainan 710, Taiwan
6Department of Medical Education, Far Eastern Memorial Hospital, New Taipei 220, Taiwan
7Department of Biochemistry, Nihon Pharmaceutical University, Saitama 362-0806, Japan
8Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
9Department of Pharmacology, China Medical University, Taichung 40402, Taiwan

Received 17 August 2011; Revised 21 October 2011; Accepted 28 October 2011

Academic Editor: José Luis Ríos

Copyright © 2012 Yu-Hsuan Lan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. M. Center, A. Jemal, R. A. Smith, and E. Ward, “Worldwide variations in colorectal cancer,” CA Cancer Journal for Clinicians, vol. 59, no. 6, pp. 366–378, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Y. Tan, C. B. Liu, A. H. Chen, Y. J. Ding, H. Y. Jin, and F. Seow-Choen, “The role of traditional Chinese medicine in colorectal cancer treatment,” Techniques in Coloproctology, vol. 12, no. 1, pp. 1–6, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. B. Hu, K.-P. Shen, H.-M. An, Y. Wu, and Q. Du, “Aqueous extract of curcuma aromatica induces apoptosis and G2/M arrest in human colon carcinoma LS-174-T cells independent of p53,” Cancer Biotherapy and Radiopharmaceuticals, vol. 26, no. 1, pp. 97–104, 2011. View at Publisher · View at Google Scholar
  4. B. Cao, S. T. Li, Z. Li, and W. L. Deng, “Yiqi Zhuyu Decoction Combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer,” Chinese Journal of Integrative Medicine, vol. 17, no. 8, pp. 593–599, 2011. View at Google Scholar
  5. W. Y. Cheng, S. L. Wu, C. Y. Hsiang et al., “Relationship between San-Huang-Xie-Xin-Tang and its herbal components on the gene expression profiles in HepG2 cells,” American Journal of Chinese Medicine, vol. 36, no. 4, pp. 783–797, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. D. W. Meek, “Mechanisms of switching on p53: a role for covalent modification?” Oncogene, vol. 18, no. 53, pp. 7666–7675, 1999. View at Google Scholar · View at Scopus
  7. S. Bates and K. H. Vousden, “Mechanisms of p53-mediated apoptosis,” Cellular and Molecular Life Sciences, vol. 55, no. 1, pp. 28–37, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. Y.-J. Chiu, M.-J. Hour, C.-C. Lu et al., “Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway,” Journal of Orthopaedic Research, vol. 29, no. 9, pp. 1448–1456, 2011. View at Publisher · View at Google Scholar
  9. C. Y. Chuang, H. C. Liu, L. C. Wu, C. Y. Chen, J. T. Chang, and S. L. Hsu, “Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway,” Journal of Agricultural and Food Chemistry, vol. 58, no. 5, pp. 2943–2951, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. B. S. Shylesh and J. Padikkala, “In vitro cytotoxic and antitumor property of Emilia sonchifolia (L.) DC in mice,” Journal of Ethnopharmacology, vol. 73, no. 3, pp. 495–500, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. U.-H. Lan, Y.-C. Wu, K.-W. Wu et al., “Death receptor 5-mediated TNFR family signaling pathways modulate γ-humulene-induced apoptosis in human colorectal cancer HT29 cells,” Oncology Reports, vol. 25, no. 2, pp. 419–424, 2011. View at Publisher · View at Google Scholar
  12. V. M. Couto, F. C. Vilela, D. F. Dias et al., “Antinociceptive effect of extract of Emilia sonchifolia in mice,” Journal of Ethnopharmacology, vol. 134, no. 2, pp. 348–353, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. K. N. Muko and F. C. Ohiri, “A preliminary study on the anti-inflammatory properties of Emilia sonchifolia leaf extracts,” Fitoterapia, vol. 71, no. 1, pp. 65–68, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. T. R. Wilson, K. M. McLaughlin, M. McEwan et al., “c-FLIP: a key regulator of colorectal cancer cell death,” Cancer Research, vol. 67, no. 12, pp. 5754–5762, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. H. Chang, J. S. Yang, S. C. Kuo, and J. G. Chung, “Induction of mitotic arrest and apoptosis by a novel synthetic quinolone analogue, CWC-8, via intrinsic and extrinsic apoptotic pathways in human osteogenic sarcoma U-2 OS cells,” Anticancer Research, vol. 29, no. 8, pp. 3139–3148, 2009. View at Google Scholar · View at Scopus
  16. P.-P. Wu, K.-C. Liu, W.-W. Huang et al., “Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway,” Oncology Reports, vol. 25, no. 2, pp. 551–557, 2011. View at Publisher · View at Google Scholar
  17. J.-H. Chiang, J.-S. Yang, C.-Y. Ma et al., “Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways,” Chemical Research in Toxicology, vol. 24, no. 1, pp. 20–29, 2011. View at Publisher · View at Google Scholar
  18. J. G. Chung, J. S. Yang, L. J. Huang et al., “Proteomic approach to studying the cytotoxicity of YC-1 on U937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice,” Proteomics, vol. 7, no. 18, pp. 3305–3317, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. J. S. Yang, M. J. Hour, W. W. Huang, K. L. Lin, S. C. Kuo, and J. G. Chung, “MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells,” Journal of Pharmacology and Experimental Therapeutics, vol. 334, no. 2, pp. 477–488, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. J. S. Yang, G. W. Chen, T. C. Hsia et al., “Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways,” Food and Chemical Toxicology, vol. 47, no. 1, pp. 171–179, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. K.-T. Chen, M.-J. Hour, S.-C. Tsai et al., “The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino) quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor,” International Journal of Oncology, vol. 39, no. 3, pp. 611–619, 2011. View at Publisher · View at Google Scholar
  22. C. C. Lu, J. S. Yang, A. C. Huang et al., “Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells,” Molecular Nutrition and Food Research, vol. 54, no. 7, pp. 967–976, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. K.-C. Liu, A.-C. Huang, P.-P. Wu et al., “Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways,” Oncology Reports, vol. 26, no. 1, pp. 177–184, 2011. View at Publisher · View at Google Scholar
  24. B.-C. Ji, W. H. Hsu, J. S. Yang et al., “Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo,” Journal of Agricultural and Food Chemistry, vol. 57, no. 16, pp. 7596–7604, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. J. K. Shen, H. P. Du, M. Yang, Y. G. Wang, and J. Jin, “Casticin induces leukemic cell death through apoptosis and mitotic catastrophe,” Annals of Hematology, vol. 88, no. 8, pp. 743–752, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. J. C. Chen, K. W. Lu, M. L. Tsai et al., “Gypenosides induced G0/G1 arrest via CHk2 and apoptosis through endoplasmic reticulum stress and mitochondria-dependent pathways in human tongue cancer SCC-4 cells,” Oral Oncology, vol. 45, no. 3, pp. 273–283, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. F.-S. Yu, J.-S. Yang, C.-S. Yu et al., “Safrole induces apoptosis in human oral cancer HSC-3 cells,” Journal of Dental Research, vol. 90, no. 2, pp. 168–174, 2011. View at Publisher · View at Google Scholar
  28. C.-C. Lin, C.-L. Kuo, M.-H. Lee et al., “Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways,” International Journal of Oncology, vol. 39, no. 1, pp. 217–224, 2011. View at Publisher · View at Google Scholar
  29. M.-J. Fan, Y.-C. Lin, H.-D. Shih et al., “Crude axtracts of Agaricus brasiliensis induce apoptosis in human oral cancer CAL 27 cells through a mitochondria-dependent pathway,” In Vivo, vol. 25, no. 3, pp. 355–366, 2011. View at Google Scholar
  30. S. Haupt, M. Berger, Z. Goldberg, and Y. Haupt, “Apoptosis—the p53 network,” Journal of Cell Science, vol. 116, no. 20, pp. 4077–4085, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. J. M. Matés, J. A. Segura, F. J. Alonso, and J. Márquez, “Anticancer antioxidant regulatory functions of phytochemicals,” Current Medicinal Chemistry, vol. 18, no. 15, pp. 2315–2338, 2011. View at Google Scholar
  32. Y. Li, Y. Mao, P. W. Brandt-Rauf, A. C. Williams, and R. L. Fine, “Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway,” Molecular Cancer Therapeutics, vol. 4, no. 6, pp. 901–909, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. N. R. Rodrigues, A. Rowan, M. E. F. Smith et al., “p53 mutations in colorectal cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 87, no. 19, pp. 7555–7559, 1990. View at Google Scholar · View at Scopus
  34. O. Popanda, C. Zheng, J. R. Magdeburg et al., “Mutation analysis of replicative genes encoding the large subunits of DNA polymerase α and replication factors A and C in human sporadic colorectal cancers,” International Journal of Cancer, vol. 89, no. 2, pp. 318–324, 2000. View at Google Scholar · View at Scopus
  35. Y. S. Lee, S. Yoon, M. S. Park, J. H. Kim, J. H. Lee, and C. W. Song, “Influence of p53 expression on sensitivity of cancer cells to bleomycin,” Journal of Biochemical and Molecular Toxicology, vol. 24, no. 4, pp. 260–269, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. H. Nagasawa, C. Y. Li, C. G. Maki, A. C. Imrich, and J. B. Little, “Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells,” Cancer Research, vol. 55, no. 9, pp. 1842–1846, 1995. View at Google Scholar · View at Scopus
  37. G. Achanta, R. Sasaki, L. Feng et al., “Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol γ,” EMBO Journal, vol. 24, no. 19, pp. 3482–3492, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Tyagi, K. Bhui, R. Singh, M. Singh, S. Raisuddin, and Y. Shukla, “Polo-like kinase1 (Plk1) knockdown enhances cisplatin chemosensitivity via up-regulation of p73α in p53 mutant human epidermoid squamous carcinoma cells,” Biochemical Pharmacology, vol. 80, no. 9, pp. 1326–1334, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. S. J. He, G. Stevens, A. W. Braithwaite, and M. R. Eccles, “Transfection of melanoma cells with antisense PAX3 oligonucleotides additively complements cisplatin-induced cytotoxicity,” Molecular Cancer Therapeutics, vol. 4, no. 6, pp. 996–1003, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Müller, S. Wilder, D. Bannasch et al., “p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs,” Journal of Experimental Medicine, vol. 188, no. 11, pp. 2033–2045, 1998. View at Publisher · View at Google Scholar · View at Scopus
  41. C. Burz, I. Berindan-Neagoe, O. Balacescu, and A. Irimie, “Apoptosis in cancer: key molecular signaling pathways and therapy targets,” Acta Oncologica, vol. 48, no. 6, pp. 811–821, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Caroppi, F. Sinibaldi, L. Fiorucci, and R. Santucci, “Apoptosis and human diseases: mitochondrion damage and lethal role of released cytochrome c as proapoptotic protein,” Current Medicinal Chemistry, vol. 16, no. 31, pp. 4058–4065, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. U. Testa, “TRAIL/TRAIL-R in hematologic malignancies,” Journal of Cellular Biochemistry, vol. 110, no. 1, pp. 21–34, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. K. Kuribayashi, N. Finnberg, J. R. Jeffers, G. P. Zambetti, and W. S. El-Deiry, “The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo,” Cell Cycle, vol. 10, no. 14, pp. 2380–2389, 2011. View at Publisher · View at Google Scholar
  45. A. Ashkenazi, “Targeting the extrinsic apoptosis pathway in cancer,” Cytokine and Growth Factor Reviews, vol. 19, no. 3-4, pp. 325–331, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. I. Gradzka, “Mechanisms and regulation of the programmed cell death,” Postepy biochemii, vol. 52, no. 2, pp. 157–165, 2006. View at Google Scholar · View at Scopus