Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis
Figure 5
Effect of isocupressic acid on steroidogenesis in MA-10 cells incubated with 22R-OHC or pregnenolone. MA-10 cells were incubated with or without 22R-OHC (1 μg/mL) and treated with different doses of IA for 0.5 h (a) or 4 h (b). MA-10 cells were also incubated with or without pregnenolone (1 μg/mL) and treated different doses of IA for 0.5 h (c) or 4 h (d). The culture medium was collected, and progesterone concentration was determined by EIA. Results are expressed as mean ± SEM. Each column with different letters is significantly different at .
