Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo

Table 3

Evaluation of capsaicin-induced CGRP expression in the presence or absence of ASE in the SH-SY5Y and SK-N-BE(2) neuroblastoma cell lines.

Test substance	SH-SY5Y		SK-N-BE(2)
	pg/mL	% of inhibition	pg/mL	% of inhibition
Capsaicin 300 nM + ASE 1 ppm	27.2 ± 2.9*	97.7	5.3 ± 1.3	79.0
Capsaicin 300 nM + ASE 10 ppm	24.6 ± 3.8*	104.0	4.6 ± 0.2*	108.4
Capsaicin 300 nM	66.6 ± 11.9	0	7.2 ± 0.8	0
Control	26.3 ± 2.1	100	4.8 ± 1.2	100

* 𝑃<0.05 compared with capsaicin-treated group values.