Neuroprotective Effect of Uncaria rhynchophylla in Kainic Acid-Induced Epileptic Seizures by Modulating Hippocampal Mossy Fiber Sprouting, Neuron Survival, Astrocyte Proliferation, and S100B Expression
The alteration of electroencephalographic (EEG) signals in KA-injected animals. Basal EEG activity from the sensorimotor cortex was characterized by 6–8 Hz activity in rats when awake (a). KA-induced temporal lobe seizures, including wet dog shakes (WDS) with intermittent polyspike-like activity (b), facial myoclonia with continuous sharp waves (c) and paw tremor (PT) with continuous spike activity (d). Lt Cx = EEG recording from the left sensorimotor cortex; Rt Cx = EEG recording from the right sensorimotor cortex; EMG = EMG recording from the neck muscle.
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