Table of Contents Author Guidelines Submit a Manuscript
Table of Contents Alerts

To receive news and publication updates for Evidence-Based Complementary and Alternative Medicine, enter your email address in the box below.

Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 196358, 9 pages
http://dx.doi.org/10.1155/2012/196358
Research Article

Long-Term Oral Administration of Capsicum baccatum Extracts Does Not Alter Behavioral, Hematological, and Metabolic Parameters in CF1 Mice

Aline Rigon Zimmer,1 Bianca Leonardi,1 Eduardo Rigon Zimmer,2 Eduardo Kalinine,2 Diogo Onofre de Souza,2 Luis Valmor Portela,2 and Grace Gosmann1

1Pharmaceutical Sciences Graduate Program, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Ipiranga Avendia 2752, 90610-000 Porto Alegre, RS, Brazil
2Post-Graduate Program in Biological Science, Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street 2600, 90035-003 Porto Alegre, RS, Brazil

Received 13 August 2012; Revised 20 November 2012; Accepted 21 November 2012

Academic Editor: Jenny M. Wilkinson

Copyright © 2012 Aline Rigon Zimmer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. S. Govindarajan, “Capsicum production, technology, chemistry, and quality. Part 1: History, botany, cultivation, and primary processing,” Critical Reviews in Food Science and Nutrition, vol. 22, no. 2, pp. 109–176, 1985. View at Google Scholar · View at Scopus
  2. J. Pino, M. González, L. Ceballos et al., “Characterization of total capsaicinoids, colour and volatile compounds of Habanero chilli pepper (Capsicum chinense Jack.) cultivars grown in Yucatan,” Food Chemistry, vol. 104, no. 4, pp. 1682–1686, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Ochi, Y. Takaishi, K. Kogure, and I. Yamauti, “Antioxidant activity of a new capsaicin derivative from Capsicum annuum,” Journal of Natural Products, vol. 66, no. 8, pp. 1094–1096, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Topuz and F. Ozdemir, “Assessment of carotenoids, capsaicinoids and ascorbic acid composition of some selected pepper cultivars (Capsicum annuum L.) grown in Turkey,” Journal of Food Composition and Analysis, vol. 20, no. 7, pp. 596–602, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Materska and I. Perucka, “Antioxidant activity of the main phenolic compounds isolated from hot pepper fruit (Capsicum annuum L.),” Journal of Agricultural and Food Chemistry, vol. 53, no. 5, pp. 1750–1756, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Menichini, R. Tundis, M. Bonesi et al., “The influence of fruit ripening on the phytochemical content and biological activity of Capsicum chinense Jacq. cv Habanero,” Food Chemistry, vol. 114, no. 2, pp. 553–560, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. A. P. Muller, J. Gnoatto, J. D. Moreira et al., “Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice,” Hippocampus, vol. 21, pp. 1082–1092, 2011. View at Google Scholar
  8. J. Barnes J, L. A. Anderson, and J. D. Phillipson, Herbal Medicines, Pharmaceutical Press, London, UK, 3rd edition, 2007.
  9. K. D. K. Ahuja, I. K. Robertson, D. P. Geraghty, and M. J. Ball, “The effect of 4-week chilli supplementation on metabolic and arterial function in humans,” European Journal of Clinical Nutrition, vol. 61, no. 3, pp. 326–333, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Aizawa and T. Inakuma, “Dietary capsanthin, the main carotenoid in paprika (Capsicum annuum), alters plasma high-density lipoprotein-cholesterol levels and hepatic gene expression in rats,” British Journal of Nutrition, vol. 102, no. 12, pp. 1760–1766, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Liu and M. G. Nair, “Capsaicinoids in the hottest pepper Bhut Jolokia and its antioxidant and antiinflammatory activities,” Natural Product Communications, vol. 5, no. 1, pp. 91–94, 2010. View at Google Scholar · View at Scopus
  12. L. G. Ranilla, Y. I. Kwon, E. Apostolidis, and K. Shetty, “Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America,” Bioresource Technology, vol. 101, no. 12, pp. 4676–4689, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Srinivasan, “Spices as influencers of body metabolism: an overview of three decades of research,” Food Research International, vol. 38, no. 1, pp. 77–86, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. R. D. Altman and H. R. Barthel, “Topical therapies for osteoarthritis,” Drugs, vol. 71, no. 10, pp. 1259–1279, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Donofrio, F. Walker, V. Hunt et al., “Treatment of painful diabetic neuropathy with topical capsaicin: a multicenter, double-blind, vehicle-controlled study,” Archives of Internal Medicine, vol. 151, no. 11, pp. 2225–2229, 1991. View at Publisher · View at Google Scholar · View at Scopus
  16. V. D. Kappel, G. M. Costa, G. Scola et al., “Phenolic content and antioxidant and antimicrobial properties of fruits of Capsicum baccatum L. var. pendulum at different maturity stages,” Journal of Medicinal Food, vol. 11, no. 2, pp. 267–274, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Kollmannsberger, A. Rodríguez-Burruezo, S. Nitz, and F. Nuez, “Volatile and capsaicinoid composition of ají (Capsicum baccatum) and rocoto (Capsicum pubescens), two Andean species of chile peppers,” Journal of the Science of Food and Agriculture, vol. 91, no. 9, pp. 1598–1611, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Rodríguez-Burruezo, M. C. González-Mas, and F. Nuez, “Carotenoid composition and vitamin A value in ají(Capsicum baccatum L.) and rocoto (C. pubescens R. & P.), 2 pepper species from the andean region,” Journal of Food Science, vol. 75, no. 8, pp. S446–S453, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. F. Spiller, M. K. Alves, S. M. Vieira et al., “Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation,” Journal of Pharmacy and Pharmacology, vol. 60, no. 4, pp. 473–478, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. A. R. Zimmer, B. Leonardi, D. Miron, E. Schapoval, J. R. de Oliveira, and G. Gosmann, “Antioxidant and anti-inflammatory properties of Capsicum baccatum: from traditional use to scientific approach,” Journal of Ethnopharmacology, vol. 139, pp. 228–233, 2012. View at Google Scholar
  21. L. O. Chuah, S. K. Yeap, W. Y. Ho, B. K. Beh, and N. B. Alitheen, “In vitro and in vivo toxicity of garcinia or hydroxycitric acid: a review,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 197920, 12 pages, 2012. View at Publisher · View at Google Scholar
  22. J. L. Leasure and L. Decker, “Social isolation prevents exercise-induced proliferation of hippocampal progenitor cells in female rats,” Hippocampus, vol. 19, no. 10, pp. 907–912, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. A. E. Whimbey and V. H. Denenberg, “Two independent behavioral dimensions in open-field performance,” Journal of Comparative and Physiological Psychology, vol. 63, no. 3, pp. 500–504, 1967. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Prut and C. Belzung, “The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review,” European Journal of Pharmacology, vol. 463, no. 1–3, pp. 3–33, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Pellow, P. Chopin, S. E. File, and M. Briley, “Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat,” Journal of Neuroscience Methods, vol. 14, no. 3, pp. 149–167, 1985. View at Google Scholar · View at Scopus
  26. P. I. Parekh, A. E. Petro, J. M. Tiller, M. N. Feinglos, and R. S. Surwit, “Reversal of diet-induced obesity and diabetes in C57BL/6J mice,” Metabolism, vol. 47, no. 9, pp. 1089–1096, 1998. View at Publisher · View at Google Scholar · View at Scopus
  27. V. Kazlauckas, N. Pagnussat, S. Mioranzza et al., “Enriched environment effects on behavior, memory and BDNF in low and high exploratory mice,” Physiology and Behavior, vol. 102, no. 5, pp. 475–480, 2011. View at Publisher · View at Google Scholar · View at Scopus