Table 1: Summary of clinical studies conducted to date on the results and safety record of HCA. Only the subjects who manage to complete the trial is counted in the table below.

Duration Mode of trialFormulationResultsSafety ConclusionReference

8 weeksParallel, randomized, double-blind, placebo control, 39 subjects1500 mg G. cambogia + 300 μg chromium picolinate/dayNo significant effect between groups Itching around mouth in both treatment and placebo groups. None toxic[43]

8 weeksParallel, randomized, double-blind, placebo control, 35 subjects1500 mg G. cambogia before meal/dayNo changes in blood glutamic oxaloacetic transaminase (SGOT), glutamic pyruvic transaminase (SGPT) and glucose. Headaches and nausea in both treatment (2) and placebo (1) groups None toxic [44]

4 weeksParallel, randomized, double-blind, placebo control, 144 subjects55 mg G. cambogia + 19 mg chromium + 240 mg chitosan/dayTreated group possessed significant weight loss, lower TC, LDL and higher HDL as compared to placeboHeadaches and nausea in both treatment (2) and placebo (1) groupsNone toxic[45]

12 weeksParallel, randomized, double blind, placebo control, 84 subjects3000 mg G. cambogia (50% HCA)/dayNo significant effect between groups Intestinal disorders, headache, or upper airway symptoms in both treatment and placebo groupsNone toxic[46]

6 weeksParallel, randomized, double blind, placebo control, 18 subjects750 mg G. cambogia + 750 mg calcium + 750 mg guggulsterone + 750 mg L-tyrosine/day No significant effect between groups Not reported[47]

12 weeksParallel, randomized, double blind, placebo control, 33 subjects300 mg G. cambogia + 1200 mg Phaseolus vulgaris + 1200 mg inulin/dayBetter weight lose in treated groupNot reported[48]

12 weeksParallel, randomized, double blind, placebo control, 89 subjects2400 mg G. cambogia/dayBetter weight lose in treated groupNot reported[49]

8 weeksParallel, randomized, double-blind, placebo-control, 82 moderate obsese subjects2800 mg HCA; 4667 mg of HCA-SX in combination with niacin-bound chromium and standardized Gymnema sylvestre extract/daySignificant weight loss, reduction in BMI, increased fat oxidation, favorable lipid profile, reduction in circulating plasma leptin levels, increase in serum serotonin levels, and decreased appetite as determined by reductions in food intake were detected in HCA-SX treatment group, and to a greater extent the combination of the 3 ingredientsNo serious adverse effects were detected, except several minor adverse effects such as leg cramps, heartburn, diarrhea, gas, increased appetite, headaches, stomach burn, and menstrual disordersNone toxic[50]

12 weeksParallel, randomized, double blind, placebo control, 98 subjectsG. cambogia + kidney bean pods + chromium yeastBetter weight lose in treated groupMore gastrointestinal symptoms in treated group. None toxic[51]

12 weeksParallel, randomized, double blind, placebo control, 44 subjects1,667.3 mg of G. cambogia extract/day (1,000 mg HCA/day)No significant effect on TG between treatment and placebo group. Answer to the concept of potential spermatogenesis impair [27]No significant reproductive toxicity on serum testosterone, estrone, and estradiol levels, hematology, serum triacylglycerol, and serum clinical pathology parametersNone toxic[52]

12 weeksParallel, randomized, double blind, placebo control, 58 subjects2400 mg G. cambogia + 1500 mg Amorphophallus konjac/dayNo significant effect between groups No significant difference between treatment and placebo groupsNone toxic [53]

2 weeks × 3 timesParallel, randomized, double blind, placebo control, 21 subjects500 mg HCA + 300 medium chain TG/dayNo significant effect between groups Not reported [54]

8 weeksParallel, randomized, single blind, placebo control, 40 subjects1000 mg of HCA/dayReduction of visceral fat area and visceral fat area/subcutaneous fat area No significant difference in hematological parameters (white blood cells, red blood cells, hemoglobin, hematocrit and platelets) and clinical chemistry parameters (SGPT, SGOT, c glutamyl transpeptidase, lactate dehydrogenase, blood urea nitrogen, creatinine, glucose, insulin, acetoacetic acid, 3-hydroxybutyric acid, and total ketone bodies) between groupsNone toxic[55]

10 daysCross-over, randomized, placebo control, 44 subjects1000, 2000, 3000 and 4000 mg G. cambogia/dayNo significant different in hematology and clinical chemistry analysis before and after treatment no unusual electrocardiographic effects.NOAEL > 4 g HCA[56]

5 hoursCross-over, randomized, double blind, placebo control, 20 subjects extracts of, G. cambogia, green tea, caffeine, and yerba mateNo unusual electrocardiographic effects.[57]

??Cross-over, randomized, double blind, placebo control5600 mg HCA/day ??Yet to be published??[58]

2 weeksCross-over, randomized, single blind, placebo control, 24 subjects900 mg HCA/dayDecreased energy intakeNo adverse effectNone toxic [59]