JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats

<table>Effects of JCM-16021 on visceral hypersensitivity of PI-IBS rats. (a) depicts the analgesic effect of JCM-16021 in PI-IBS rats in terms of pain threshold pressure, while (b) depicts the effect of JCM-16021 on visceral motor response to graded CRD in PI-IBS rats. The representative EMG graphs from normal rats, PI-IBS rats, and high-dose JCM-16021 treated rats in a 20 s noxious (80 mmHg) colorectal distension period are shown in (c). Data are presented as mean ± S.E.M., <svg height="10.925" id="M7" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> per group in AWR test, <svg height="11.125" id="M8" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.125" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> per group in EMG recording test. <svg height="19.65" id="M9" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 70.224998 19.65" width="70.224998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus normal rats, <svg height="17.825001" id="M10" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, versus PI-IBS rats (<i>t</i>-test).</table>

Evidence-Based Complementary and Alternative Medicine

fig1

Figure 1

Figure 1: JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats 

Figure 1 | JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats 