JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats

<table>Effect of JCM-16021 on mechanical stimuli (CRD) induced 5-HT release in PI-IBS rats. (a) shows the statistical analysis of colonic 5-HT content in PI-IBS rats with or without CRD treatment. (b) shows the representative electron microsgraphs of EC cells and their secretory granules (inset) from the (B1) normal rats, (B2) PI-IBS rats, and (B3) high dose JCM-16021 treated rats (×8900; inset: ×10000). Activated EC cell is characterized by the clear secretory granules without cores (red arrow), or secretory granules with eccentric cores (red arrowhead) in it. Data are shown as mean ± S.E.M., <svg height="10.925" id="M32" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus the same group without CRD treatment (<i>t</i>-test).</table>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats 

Figure 5 | JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats 