Comparative Effects of Er-Xian Decoction, Epimedium Herbs, and Icariin with Estrogen on Bone and Reproductive Tissue in Ovariectomized Rats

Table 1

Mineral density and bone histomorphometric parmeters of proximal tibial cancellous bone.

Groups	Sham	OVX	NYL	ICA	EBH	EXD
BMD (g/cm^2)	0.26 ± 0.01*	0.25 ± 0.01	0.26 ± 0.01*	0.26 ± 0.01*	0.26 ± 0.01*	0.26 ± 0.01*
Trabecular area ratio (%)	21.37 ± 3.42**	5.32 ± 1.09	19.04 ± 3.28**	10.69 ± 2.22**	13.82 ± 3.71**	18.33 ± 2.47**
Trabecular thickness (μm )	62.42 ± 6.06*	43.57 ± 3.40	63.75 ± 6.39*	56.54 ± 4.72*	54.71 ± 5.16*	60.78 ± 7.02*
Trabecular number (#/mm)	3.17 ± 0.47**	1.31 ± 0.22	2.79 ± 0.31**	1.84 ± 0.24	2.34 ± 0.41**	2.67 ± 0.28**
Trabecular separation (μm )	209.73 ± 40.40**	1007.36 ± 127.63	342.57 ± 37.33**	631.77 ± 58.61*	573.75 ± 62.31*	441.81 ± 51.26*
MAR (μm/d)	0.59 ± 0.19**	1.18 ± 0.24	0.77 ± 0.11*	1.26 ± 0.19	1.08 ± 0.22	0.81 ± 0.19*
BFR/BS (mcm/d*100)	14.62 ± 1.85**	36.88 ± 4.71	17.62 ± 2.02**	31.65 ± 8.76	33.82 ± 4.71	18.23 ± 2.57*
BFR/BV (%/year)	139.62 ± 24.86**	302.55 ± 46.37	163.18 ± 25.72**	314.82 ± 28.66	317.65 ± 47.51	208.39 ± 26.12*
Osteoclast number (#/mm)	7.47 ± 1.25**	18.84 ± 3.67	8.84 ± 2.24**	9.96 ± 2.42**	9.21 ± 1.68**	7.96 ± 2.19**

The data represent the mean ± standard deviation (𝑛=8), *P < 0.05, **P < 0.01 compared with OVX group.