Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 241583, 9 pages
http://dx.doi.org/10.1155/2012/241583
Research Article

Protective Role of Phyllanthus niruri Extract against Thioacetamide-Induced Liver Cirrhosis in Rat Model

1Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
2Health and Translational Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
3Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 15 December 2011; Revised 13 February 2012; Accepted 27 February 2012

Academic Editor: Adair Roberto Soares Santos

Copyright © 2012 Zahra A. Amin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [21 citations]

The following is the list of published articles that have cited the current article.

  • Feroz Ahmad, and Nahida Tabassum, “Experimental models used for the study of antihepatotoxic agents,” Journal of Acute Disease, vol. 1, no. 2, pp. 85–89, 2012. View at Publisher · View at Google Scholar
  • Zahra A. Amin, Mohammed A. Alshawsh, Mustafa Kassim, Hapipah M. Ali, and Mahmood A. Abdulla, “Gene expression profiling reveals underlying molecular mechanism of hepatoprotective effect of Phyllanthus niruri on thioacetamide-induced hepatotoxicity in Sprague Dawley rats,” BMC Complementary and Alternative Medicine, vol. 13, 2013. View at Publisher · View at Google Scholar
  • Suzy M. Salama, Mahmood A. Abdulla, Ahmed S. AlRashdi, and A. Hamid A. Hadi, “Mechanism of Hepatoprotective Effect of Boesenbergia rotunda in Thioacetamide-Induced Liver Damage in Rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–13, 2013. View at Publisher · View at Google Scholar
  • Daleya Abdulaziz Bardi, Mohammed Farouq Halabi, Nor Azizan Abdullah, Elham Rouhollahi, Maryam Hajrezaie, and Mahmood Ameen Abdulla, “In Vivo Evaluation of Ethanolic Extract of Zingiber officinale Rhizomes for Its Protective Effect against Liver Cirrhosis,” Biomed Research International, 2013. View at Publisher · View at Google Scholar
  • Juan Gayosso-De-Lucio, Mirandeli Bautista, C. Velazquez-Gonzalez, De la O. Arciniega M, J. A. Morales-Gonzalez, and Juana Benedi, “Chemical composition and hepatotoxic effect of Geranium schiedeanum in a thioacetamide-induced liver injury model,” Pharmacognosy Magazine, vol. 10, no. 39, pp. 574–580, 2014. View at Publisher · View at Google Scholar
  • Daleya Abdulaziz Bardi, Mohammed Farouq Halabi, Pouya Hassandarvish, Elham Rouhollahi, Mohammadjavad Paydar, Soheil Zorofchian Moghadamtousi, Nahla Saeed Al-Wajeeh, Abdulwali Ablat, Nor Azizan Abdullah, and Mahmood Ameen Abdulla, “Andrographis paniculata Leaf Extract Prevents Thioacetamide-Induced Liver Cirrhosis in Rats,” Plos One, vol. 9, no. 10, 2014. View at Publisher · View at Google Scholar
  • Dnyaneshwar U. Bawankule, Karuna Shanker, Madan M. Gupta, Priyanka Trivedi, Feroz Khan, Ram K. Verma, Anirban Pal, Manju Singh, Pooja Sharma, and Anil K. Maurya, “Protective mechanism of lignans from Phyllanthus amarus against galactosamine/ lipopolysaccharide-induced hepatitis: An in-vivo and in-silico studies,” Current Topics in Medicinal Chemistry, vol. 14, no. 8, pp. 1045–1055, 2014. View at Publisher · View at Google Scholar
  • Jessa Fidel Montejo, Juan Arturo Burgos Mondonedo, Matthew Genesis Aguila Lee, Michael Bagui Ples, and Rodel Jonathan Santos Vitor, “Hematological effects of Ipomoea batatas (camote) and Phyllanthus niruri (sampa-sampalukan) from Philippines in the ICR mice (Mus musculus),” Asian Pacific Journal of Tropical Biomedicine, vol. 5, no. 1, pp. 29–33, 2015. View at Publisher · View at Google Scholar
  • Fatma A.A. Mansour, Nabiha R.A. Hassan, and Iman Shaheed, “Use of bone marrow-derived mesenchymal stem cells in improving Thioacetamide induced liver fibrosis in rats,” Springer Proceedings in Physics, vol. 164, pp. 223–228, 2015. View at Publisher · View at Google Scholar
  • Zahra A. Amin, Hapipah M. Ali, Mohammed A. Alshawsh, Pouya H. Darvish, and Mahmood A. Abdulla, “ Application of Antrodia camphorata Promotes Rat’s Wound Healing In Vivo and Facilitates Fibroblast Cell Proliferation In Vitro ,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–14, 2015. View at Publisher · View at Google Scholar
  • Dina Farouk Mansour, Somaia Ahmed Nada, Ezz-Eldeen Said Eldenshary, Berween Mahmoud Elmahmoudy, and Sherein Saeid AbdElgayed, “Antioxidant and hypo-ammonemic activities of alpha-lactalbumin and vitamin c in thioacetamide-induced liver and brain damage in rats,” Journal of Applied Pharmaceutical Science, vol. 5, no. 9, pp. 072–081, 2015. View at Publisher · View at Google Scholar
  • Nathanael Y. S. Lee, William K. S. Khoo, Mohammad Akmal Adnan, Tanes Prasat Mahalingam, Anne R Fernandez, and Kamalan Jeevaratnam, “ The pharmacological potential of Phyllanthus niruri ,” Journal of Pharmacy and Pharmacology, 2016. View at Publisher · View at Google Scholar
  • V. Pavithra Bharathi, C. Ragavendran, N. Murugan, and D. Natarajan, “ Ipomoea batatas (Convolvulaceae)-mediated synthesis of silver nanoparticles for controlling mosquito vectors of Aedes albopictus , Anopheles stephensi , and Culex quinquefasciatus (Diptera:Culicidae) ,” Artificial Cells, Nanomedicine, and Biotechnology, vol. 45, no. 8, pp. 1568–1580, 2016. View at Publisher · View at Google Scholar
  • Rafael C. Dutra, Maria M. Campos, Adair R.S. Santos, and João B. Calixto, “Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives,” Pharmacological Research, 2016. View at Publisher · View at Google Scholar
  • Alex Boye, Yan Yang, James Asenso, and Wei Wei, “Anti-fibro-hepatocarcinogenic Chinese herbal medicines: A mechanistic overview,” Journal of Intercultural Ethnopharmacology, vol. 5, no. 3, pp. 1–12, 2016. View at Publisher · View at Google Scholar
  • Mozhgan Ghobadi Pour, Naser Mirazi, Hojjatollah Alaei, Shirin Moradkhani, Ziba Rajaei, and Alireza Monsef Esfahani, “Effects of lactulose and silymarin on liver enzymes in cirrhotic rats,” Canadian Journal of Physiology and Pharmacology, vol. 95, no. 5, pp. 522–529, 2017. View at Publisher · View at Google Scholar
  • Denise Utami Putri, Ning Rintiswati, Marsetyawan HNE Soesatyo, and Sofia Mubarika Haryana, “ Immune modulation properties of herbal plant leaves: Phyllanthus niruri aqueous extract on immune cells of tuberculosis patient - in vitro study ,” Natural Product Research, pp. 1–5, 2017. View at Publisher · View at Google Scholar
  • Mohamed Abdo, Mahmoud Abdelghaffar Emam, and Sameh Mohamed Farouk, “The ameliorative potential of probiotics and/or silymarin on thioacetamide induced hepatotoxicity in rats: Histological and immunohistochemical study,” International Journal of Morphology, vol. 36, no. 2, pp. 661–669, 2018. View at Publisher · View at Google Scholar
  • Salma M. Eraky, Mohamed El-Mesery, Amro El-Karef, Laila A. Eissa, and Amal M. El-Gayar, “Silymarin and caffeine combination ameliorates experimentally-induced hepatic fibrosis through down-regulation of LPAR1 expression,” Biomedicine & Pharmacotherapy, vol. 101, pp. 49–57, 2018. View at Publisher · View at Google Scholar
  • Farkaad A. Kadir, Normadiah M. Kassim, Mahmood A. Abdulla, and Wageeh A. Yehye, “ Corrigendum to “Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide-Induced Liver Fibrosis in Male Rats” ,” Evidence-Based Complementary and Alternative Medicine, vol. 2018, pp. 1–3, 2018. View at Publisher · View at Google Scholar
  • Nancy Vargas-Mendoza, Miguel Vázquez-Velasco, Laura González-Torres, Juana Benedí, Francisco Sánchez-Muniz, Jose Morales-González, Osmar Jaramillo-Morales, Carmen Valadez-Vega, and Mirandeli Bautista, “Effect of Extract and Ellagic Acid from Geranium schiedeanum on the Antioxidant Defense System in An Induced-Necrosis Model,” Antioxidants, vol. 7, no. 12, pp. 178, 2018. View at Publisher · View at Google Scholar