Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 241583, 9 pages
http://dx.doi.org/10.1155/2012/241583
Research Article

Protective Role of Phyllanthus niruri Extract against Thioacetamide-Induced Liver Cirrhosis in Rat Model

1Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
2Health and Translational Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
3Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 15 December 2011; Revised 13 February 2012; Accepted 27 February 2012

Academic Editor: Adair Roberto Soares Santos

Copyright © 2012 Zahra A. Amin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. E. Myagmar, E. Shinno, T. Ichiba, and Y. Aniya, “Antioxidant activity of medicinal herb rhodococcum vitis-idaea on galactosamine-induced liver injury in rats,” Phytomedicine, vol. 11, no. 5, pp. 416–423, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. M. A. Alshawsh, M. A. Abdulla, S. Ismail, and Z. A. Amin, “Hepatoprotective effects of orthosiphon stamineus extract on thioacetamide-induced liver cirrhosis in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 103039, 6 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. M. E. Barros, R. Lima, L. P. Mercuri, J. R. Matos, N. Schor, and M. A. Boim, “Effect of extract of phyllanthus niruri on crystal deposition in experimental urolithiasis,” Urological Research, vol. 34, no. 6, pp. 351–357, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. V. Murugaiyah and K. L. Chan, “Mechanisms of antihyperuricemic effect of phyllanthus niruri and its lignan constituents,” Journal of Ethnopharmacology, vol. 124, no. 2, pp. 233–239, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. J. B. Calixto, A. R. S. Santos, and R. A. Yunes, “A review of the plants of the genus Phyllanthus: their chemistry, pharmacology, and therapeutic potential,” Medicinal Research Reviews, vol. 18, pp. 225–258, 1998. View at Google Scholar
  6. P. C. Eklund, O. K. Lngvik, J. P. WÃrnÃ, T. O. Salmi, S. M. WillfÃr, and R. E. SjÃholm, “Chemical studies on antioxidant mechanisms and free radical scavenging properties of lignans,” Organic & Biomolecular Chemistry, vol. 3, pp. 3336–3347, 2005. View at Google Scholar
  7. R. Harish and T. Shivanandappa, “Antioxidant activity and hepatoprotective potential of phyllanthus niruri,” Food Chemistry, vol. 95, no. 2, pp. 180–185, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Bhattacharjee and P. C. Sil, “Protein isolate from the herb, phyllanthus niruri l. (euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties,” Food and Chemical Toxicology, vol. 45, no. 5, pp. 817–826, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. A. AlBader, T. Mathew, H. Abul et al., “Thioacetamide induced changes in trace elements and kidney damage,” The Journal of Trace Elements in Experimental Medicine, vol. 12, pp. 1–14, 1999. View at Google Scholar
  10. C. N. Yeh, A. Maitra, K. F. Lee, Y. Y. Jan, and M. F. Chen, “Thioaceatamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma,” Carcinogenesis, vol. 25, no. 4, pp. 631–636, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. P. V. Kiruthiga, R. B. Shafreen, S. K. Pandian, S. Arun, S. Govindu, and K. P. Devi, “Protective effect of silymarin on erythrocyte haemolysate against benzo(a)pyrene and exogenous reactive oxygen species (H2O2) induced oxidative stress,” Chemosphere, vol. 68, no. 8, pp. 1511–1518, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. K. R. Ball and K. V. Kowdley, “A review of silybum marianum (milk thistle) as a treatment for alcoholic liver disease,” Journal of Clinical Gastroenterology, vol. 39, no. 6, pp. 520–528, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. R. R. Chattopadhyay, “Possible mechanism of hepatoprotective activity of azadirachta indica leaf extract: part ii,” Journal of Ethnopharmacology, vol. 89, no. 2-3, pp. 217–219, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. Oecd, OECD guidelines for testing of chemicals, OECD, 1998.
  15. M. A. Abdulla, K. A. A. Ahmed, F. H. Al-Bayaty, and Y. Masood, “Gastroprotective effect of phyllanthus niruri leaf extract against ethanol-induced gastric mucosal injury in rats,” African Journal of Pharmacy and Pharmacology, vol. 4, no. 5, pp. 226–230, 2010. View at Google Scholar · View at Scopus
  16. P. H. Park, J. X. Nan, E. J. Park et al., “Effect of tetrandrine on experimental hepatic fibrosis induced by bile duct ligation and scission in rats,” Pharmacology and Toxicology, vol. 87, no. 6, pp. 261–268, 2000. View at Google Scholar · View at Scopus
  17. A. A. Basma, Z. Zakaria, L. Y. Latha, and S. Sasidharan, “Antioxidant activity and phytochemical screening of the methanol extracts of euphorbia hirta l,” Asian Pacific Journal of Tropical Medicine, vol. 4, no. 5, pp. 386–390, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Cassiman, L. Libbrecht, V. Desmet, C. Denef, and T. Roskams, “Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers,” Journal of Hepatology, vol. 36, no. 2, pp. 200–209, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. T. S. M. Saleem, C. M. Chetty, S. Ramkanth, V. S. T. Rajan, K. Mahesh Kumar, and K. Gauthaman, “Hepatoprotective herbs—a review,” International Journal of Research in Pharmaceutical Sciences, vol. 1, no. 1, pp. 1–5, 2010. View at Google Scholar · View at Scopus
  20. S. L. Friedman, “Liver fibrosis—from bench to bedside,” Journal of Hepatology, Supplement, vol. 38, no. 1, pp. S38–S53, 2003. View at Google Scholar · View at Scopus
  21. S. K. Natarajan, S. Thomas, P. Ramamoorthy et al., “Oxidative stress in the development of liver cirrhosis: a comparison of two different experimental models,” Journal of Gastroenterology and Hepatology, vol. 21, no. 6, pp. 947–957, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Sato, M. Kakubari, M. Kawamura, J. Sugimoto, K. Matsumoto, and T. Ishii, “The decrease in total collagen fibers in the liver by hepatocyte growth factor after formation of cirrhosis induced by thioacetamide,” Biochemical Pharmacology, vol. 59, no. 6, pp. 681–690, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Galisteo, A. Suárez, M. P. Montilla, M. I. Fernandez, A. Gil, and M. C. Navarro, “Protective effects of rosmarinus tomentosus ethanol extract on thioacetamide-induced liver cirrhosis in rats,” Phytomedicine, vol. 13, no. 1-2, pp. 101–108, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Bruck, O. Genina, H. Aeed et al., “Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats,” Hepatology, vol. 33, no. 2, pp. 379–386, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. G. Kumar, G. S. Banu, P. V. Pappa, M. Sundararajan, and M. R. Pandian, “Hepatoprotective activity of trianthema portulacastrum l. Against paracetamol and thioacetamide intoxication in albino rats,” Journal of Ethnopharmacology, vol. 92, no. 1, pp. 37–40, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Madani, M. Talebolhosseini, S. Asgary, and G. H. Naderi, “Hepatoprotective activity of silybum marianum and cichorium intybus against thioacetamide in rat,” Pakistan Journal of Nutrition, vol. 7, no. 1, pp. 172–176, 2008. View at Google Scholar · View at Scopus
  27. S. Sunitha, M. Nagaraj, and P. Varalakshmi, “Hepatoprotective effect of lupeol and lupeol linoleate on tissue antioxidant defence system in cadmium-induced hepatotoxicity in rats,” Fitoterapia, vol. 72, no. 5, pp. 516–523, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. J. W. Lee, K. D. Shin, M. Lee et al., “Role of metabolism by flavin-containing monooxygenase in thioacetamide-induced immunosuppression,” Toxicology Letters, vol. 136, no. 3, pp. 163–172, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Chilakapati, M. C. Korrapati, R. A. Hill, A. Warbritton, J. R. Latendresse, and H. M. Mehendale, “Toxicokinetics and toxicity of thioacetamide sulfoxide: a metabolite of thioacetamide,” Toxicology, vol. 230, no. 2-3, pp. 105–116, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Balkan, S. Dogğru-Abbasoğlul, Ö Kanbaglil, U. Çevikbas, G. Aykaç-Toker, and M. Uysal, “Taurine has a protective effect against thioacetamide-induced liver cirrhosis by decreasing oxidative stress,” Human and Experimental Toxicology, vol. 20, no. 5, pp. 251–254, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Sun, S. Hayami, Y. Ogiri et al., “Evaluation of oxidative stress based on lipid hydroperoxide, vitamin c and vitamin e during apoptosis and necrosis caused by thioacetamide in rat liver,” Biochimica et Biophysica Acta, vol. 1500, no. 2, pp. 181–185, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Galisteo, A. Suárez, M. P. Montilla, M. I. Fernandez, A. Gil, and M. C. Navarro, “Protective effects of rosmarinus tomentosus ethanol extract on thioacetamide-induced liver cirrhosis in rats,” Phytomedicine, vol. 13, no. 1-2, pp. 101–108, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. O. A. Gressner, R. Weiskirchen, and A. M. Gressner, “Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests,” Clinica Chimica Acta, vol. 381, no. 2, pp. 107–113, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. N. Kaplowitz, “Drug-induced liver disorders: implications for drug development and regulation,” Drug Safety, vol. 24, no. 7, pp. 483–490, 2001. View at Google Scholar · View at Scopus
  35. T. Y. Low, C. K. leow, M. Salto-Tellez, and M. C. M. Chung, “A proteomic analysis of thioacetamide-induced hepatotoxicity and cirrhosis in rat livers,” Proteomics, vol. 4, no. 12, pp. 3960–3974, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Papetti, M. Daglia, and G. Gazzani, “Anti- and pro-oxidant activity of water soluble compounds in cichorium intybus var. silvestre (treviso red chicory),” Journal of Pharmaceutical and Biomedical Analysis, vol. 30, no. 4, pp. 939–945, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. S. M. Sabir and J. B. T. Rocha, “Water-extractable phytochemicals from phyllanthus niruri exhibit distinct in vitro antioxidant and in vivo hepatoprotective activity against paracetamol-induced liver damage in mice,” Food Chemistry, vol. 111, no. 4, pp. 845–851, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Chatterjee and P. C. Sil, “Hepatoprotective effect of aqueous extract of phyllanthus niruri on nimesulide-induced oxidative stress in vivo,” Indian Journal of Biochemistry and Biophysics, vol. 43, no. 5, pp. 299–305, 2006. View at Google Scholar · View at Scopus
  39. G. Poli, “Pathogenesis of liver fibrosis: role of oxidative stress,” Molecular Aspects of Medicine, vol. 21, no. 3, pp. 49–98, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. C. Rice-Evans, “Plant polyphenols: free radical scavengers or chain-breaking antioxidants?” Biochemical Society Symposium, vol. 61, pp. 103–116, 1995. View at Google Scholar · View at Scopus
  41. M. Fauré, E. Lissi, R. Torres, and L. A. Videla, “Antioxidant activities of lignans and flavonoids,” Phytochemistry, vol. 29, no. 12, pp. 3773–3775, 1990. View at Google Scholar · View at Scopus
  42. T. Masuda, J. Akiyama, A. Fujimoto, S. Yamauchi, T. Maekawa, and Y. Sone, “Antioxidation reaction mechanism studies of phenolic lignans, identification of antioxidation products of secoisolariciresinol from lipid oxidation,” Food Chemistry, vol. 123, no. 2, pp. 442–450, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. T. A. Ajith, U. Hema, and M. S. Aswathy, “Zingiber officinale roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status,” Food and Chemical Toxicology, vol. 45, no. 11, pp. 2267–2272, 2007. View at Publisher · View at Google Scholar · View at Scopus