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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 249217, 7 pages
http://dx.doi.org/10.1155/2012/249217
Research Article

Cordyceps militaris Grown on Germinated Soybean Induces G2/M Cell Cycle Arrest through Downregulation of Cyclin B1 and Cdc25c in Human Colon Cancer HT-29 Cells

Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Republic of Korea

Received 8 November 2011; Revised 2 January 2012; Accepted 2 January 2012

Academic Editor: Raffaele Capasso

Copyright © 2012 Mohammad Lalmoddin Mollah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. T. Hawk and B. Levin, “Colorectal cancer prevention,” Journal of Clinical Oncology, vol. 23, no. 2, pp. 378–391, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Farhana, M. Dawson, A. K. Rishi et al., “Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway,” Cancer Research, vol. 62, no. 13, pp. 3842–3849, 2002. View at Google Scholar · View at Scopus
  3. Y. C. Hseu, S. C. Chen, P. C. Tsai et al., “Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata,” Food and Chemical Toxicology, vol. 45, no. 7, pp. 1107–1115, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Y. Jin, Y. H. Choi, D. O. Moon et al., “Induction of G2/M arrest and apoptosis in human gastric epithelial AGS cells by aqueous extract of Agaricus blazei,” Oncology Reports, vol. 16, no. 6, pp. 1349–1355, 2006. View at Google Scholar · View at Scopus
  5. K. C. Kim, J. S. Kim, J. K. Son, and I. G. Kim, “Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells by the Ganoderma lucidum and Duchesnea chrysantha extracts,” Cancer Letters, vol. 246, no. 1-2, pp. 210–217, 2007. View at Publisher · View at Google Scholar
  6. H. L. Yang, C. S. Chen, W. H. Chang et al., “Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata,” Cancer Letters, vol. 231, no. 2, pp. 215–227, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Park, S. H. Hong, J. Y. Lee et al., “Growth inhibition of U937 leukemia cells by aqueous extract of Cordyceps militaris through induction of apoptosis,” Oncology Reports, vol. 13, no. 6, pp. 1211–1216, 2005. View at Google Scholar · View at Scopus
  8. H. Lee, Y. J. Kim, H. W. Kim, D. H. Lee, M. K. Sung, and T. Park, “Induction of apoptosis by Cordyceps militaris through activation of caspase-3 in leukemia HL-60 cells,” Biological and Pharmaceutical Bulletin, vol. 29, no. 4, pp. 670–674, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. C. S. Kim, S. Y. Lee, S. H. Cho et al., “Cordyceps militaris induces the IL-18 expression via its promoter activation for IFN-γ production,” Journal of Ethnopharmacology, vol. 120, no. 3, pp. 366–371, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Y. Han, J. Im, J. N. Choi et al., “Induction of IL-8 expression by Cordyceps militaris grown on germinated soybeans through lipid rafts formation and signaling pathways via ERK and JNK in A549 cells,” Journal of Ethnopharmacology, vol. 127, no. 1, pp. 55–61, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Y. Kim, W. S. Ko, J. Y. Lee et al., “Water extract of Cordyceps militaris enhances maturation of murine bone marrow-derived dendritic cells in vitro,” Biological and Pharmaceutical Bulletin, vol. 29, no. 2, pp. 354–360, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Y. Jin, G. Y. Kim, and Y. H. Choi, “Induction of apoptosis by aqueous extract of Cordyceps militaris through activation of caspases and inactivation of Akt in human breast cancer MDA-MB-231 cells,” Journal of Microbiology and Biotechnology, vol. 18, no. 12, pp. 1997–2003, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Y. Oh, W.-S. Choi, C. H. Lee, and H.-J. Park, “The ethyl acetate extract of Cordyceps militaris inhibits IgE-mediated allergic responses in mast cells and passive cutaneous anaphylaxis reaction in mice,” Journal of Ethnopharmacology, vol. 135, no. 2, pp. 422–429, 2011. View at Publisher · View at Google Scholar
  14. R. D. Seon, S.-H. Kim, and D.-S. Lee, “Anti-proliferative effect of polysaccharides from Salicornia herbacea on induction of G2/M arrest and apoptosis in human colon cancer cells,” Journal of Microbiology and Biotechnology, vol. 19, no. 11, pp. 1482–1489, 2009. View at Publisher · View at Google Scholar
  15. Y. Ohta, J. B. Lee, K. Hayashi, A. Fujita, D. K. Park, and T. Hayashi, “In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans,” Journal of Agricultural and Food Chemistry, vol. 55, no. 25, pp. 10194–10199, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani, “Global cancer statistics, 2002,” Ca-A Cancer Journal for Clinicians, vol. 55, no. 2, pp. 74–108, 2005. View at Google Scholar · View at Scopus
  17. C. J. Sherr, “Principles of tumor suppression,” Cell, vol. 116, no. 2, pp. 235–246, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Z. Fang, Y. Wang, N. Ai et al., “Tea polyphenol (−)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines,” Cancer Research, vol. 63, no. 22, pp. 7563–7570, 2003. View at Google Scholar · View at Scopus
  19. S. T. Huang, R. C. Yang, L. J. Yang, P. N. Lee, and J. H. S. Pang, “Phyllanthus urinaria triggers the apoptosis and Bcl-2 down-regulation in Lewis lung carcinoma cells,” Life Sciences, vol. 72, no. 15, pp. 1705–1716, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. M. A. Hoyt, “A new checkpoint takes shape,” Nature Cell Biology, vol. 6, no. 9, pp. 801–803, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. B. C. Dash and W. S. El-Deiry, “Cell cycle checkpoint control mechanisms that can be disrupted in cancer,” Methods in Molecular Biology, vol. 280, pp. 99–161, 2004. View at Google Scholar · View at Scopus
  22. W. R. Taylor and G. R. Stark, “Regulation of the G2/M transition by p53,” Oncogene, vol. 20, no. 15, pp. 1803–1815, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. W. T. Hsieh, K. Y. Huang, H. Y. Lin, and J. G. Chung, “Physalis angulata induced G2/M phase arrest in human breast cancer cells,” Food and Chemical Toxicology, vol. 44, no. 7, pp. 974–983, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Li, H. Y. Cheung, Z. Zhang, G. K. L. Chan, and W. F. Fong, “Andrographolide induces cell cycle arrest at G2/M phase and cell death in HepG2 cells via alteration of reactive oxygen species,” European Journal of Pharmacology, vol. 568, no. 1–3, pp. 31–44, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Gautier, M. J. Solomon, R. N. Booher, J. F. Bazan, and M. W. Kirschner, “cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2,” Cell, vol. 67, no. 1, pp. 197–211, 1991. View at Google Scholar · View at Scopus