Evidence-Based Complementary and Alternative Medicine

Research Article

Systematic Review of Chinese Herbal Medicines for Preventing in-Stent Coronary Restenosis after Percutaneous Coronary Intervention

Table 1

Characteristics of baseline, diagnosis, intervention, and outcomes in included studies.


Author, year	No. of patients (T/C)	Baseline characteristics of treatment and control groups	Intervention		CAD diagnostic guidelines	PCI type	Treatment course (mos)	Followup (mos)	Outcomes
			Control	Treatment

An et al. 2009 [41]	100 (60/40)	Similar in age and sex between the two groups (narrative only)	RWM	RWM plus Yi qi hua yu fang	AG	Stent	3	3	Restenosis
Bao et al. 2005 [42]	76 (32/44)	Age, sex, hypertension, diabetes, hyperlipidemia, smoking, lesion distribution, stent number	RWM	RWM plus Ge gen shu tablet	AG	Stent	3	6	Restenosis
Chen et al. 2005 [43]	80 (40/40)	Age, sex, hypertension, diabetes, hyperlipidemia, smoking, lesion number	RWM	RWM plus Lei gong teng glycosides	AG	Stent	6	6	Restenosis, repeat intervention, MLD
Chen et al. 2005 [44]	86 (43/43)	Age, sex, CAD classification, results and characteristics of AG before PCI	RWM	RWM plus Dan shen injection	AG	Stent	1	6	Restenosis, death, recurrent angina, AMI
Chu et al. 2009 [45]	57 (28/29)	Age, sex, hypertension, diabetes, smoking, course of CAD, BMI, blockage number	RWM plus placebo	RWM plus Xue fu zhu yu capsule	AG	Stent	1	1	Quality of life
Cui et al. 2010 [46]	97 (51/46)	Age, sex, CAD classification, comorbidities, lesion number, stent number	RWM	RWM plus Liang xue shen ji fang	AG	Stent	2	6	Restenosis, death, recurrent angina, CABG, repeat PCI
Dan 2009 [47]	120 (60/60)	Age, sex, hypertension, diabetes, CAD classification, stent type	RWM	RWM plus Wen yang huo xue fang	AG	PTCA or stent	3	12	Recurrent angina and accompanying symptoms
Ding et al. 2007 [48]	55 (26/29)	Average age, sex, lesions, stent (narrative only)	RWM	RWM plus Xue zhi kang capsule	AG	Stent	6	6	Restenosis
Feng et al. 2006 [49]	61 (30/31)	Similar in baseline information between the two groups (narrative only)	RWM	RWM plus Tong xin fang	AG	PTCA	6	6	Restenosis, MLD
Fu 2009 [50]	80 (40/40)	Lesion characteristics and degree, stent type (narrative only)	RWM	RWM plus Fu fang dan shen pill	AG	Stent	6	6	Restenosis, recurrent angina, AMI, repeat intervention, CABG
Gu et al. 2007 [51]	60 (30/30)	Age, sex, complications, lesion number and type, stent type	RWM	RWM plus Xue fu zhu yu pill	AG	Stent	6	6	Restenosis, recurrent angina
Guo et al. 2009 [52]	80 (40/40)	Age, sex, complications, lesion number	RWM	RWM plus Dan shen tablet	AG	DES	6	6	Restenosis, death, CABG, repeat PCI
Han 2008 [53]	60 (30/30)	Age, sex, patient characteristics, hypertension, diabetes, smoking, lesion characteristics	RWM	RWM plus Xue sai tong capsule	AG	Stent	3	3	Recurrent angina
He et al. 2010 [54]	120 (60/60)	Age, sex, hypertension, diabetes, course of CAD, lesion characteristics	RWM	RWM plus Guan tong fang	AG	BMS	5	6	Restenosis, recurrent angina, MLD, LLS, NG, LANG
Kai et al. 2008 [55]	72 (36/36)	Age, sex, CAD characteristics, lesion characteristics (narrative only)	RWM	RWM plus Tong xin luo capsule	AG	Stent	6	6	Restenosis, LLS, NG, LANG
Li et al. 2004 [56]	57 (37/20)	Age, sex, hyperlipidemia, diabetes, smoking, lesion distribution and characteristics	RWM	RWM plus Shu xue tong injection	AG	Stent	1	6	Recurrent angina, MLD, LLS, NG
Li et al. 2010 [57]	80 (42/38)	Age, sex, lesion characteristics and degree, stent type (narrative only)	RWM	RWM plus Fu fang dan shen pill	AG	Stent	6	6	Recurrent angina, MI, repeat PCI, CABG
Li et al. 2005 [58]	52 (26/26)	Age, sex, hypertension, diabetes, smoking, lesion number	RWM	RWM plus Tong guan capsule	AG	PTCA or stent	3	6	Clinical effect of AP
Li et al. 2006 [59]	80 (40/40)	Age, hypertension, diabetes, lesion number and site	RWM	RWM plus Shi ni decoction	AG	Stent	6	6	Restenosis, repeat intervention, MLD
Li et al. 2008 [60]	121 (61/60)	Age, sex, hypertension, diabetes, smoking, lesion number and lsite	RWM	RWM plus Tong mai yi xin pill	AG	PTCA	6	6	Restenosis, recurrent angina
Li et al. 2004 [61]	70 (36/34)	Age, sex, complications, lesion number (narrative only)	RWM	RWM plus Xing mai fu tong decoction	Meeting guide	Stent	3	6	Restenosis
Li 2009 [62]	151 (76/75)	Age, sex, hypertension, diabetes, smoking, lesion characteristics	RWM	RWM plus Tong mai yi xin pill	AG	Stent	6	6	Restenosis, recurrent angina
Li and Niu 2008 [63]	59 (36/33)	Age, sex, hypertension, diabetes, smoking, lesion number and degree of blockage	RWM	RWM plus Jiang lian he ji	AG	PTCA	3	6	Restenosis, recurrent angina
Liu et al.2002 [64]	75 (30/45)	Age, sex, hypertension, diabetes, smoking, lesion number and degree of blockage	RWM	RWM plus Lei gong teng glycosides	AG	Stent	6	6	Restenosis, recurrent angina, MACE, MLD, LLS, NG, LANG
Liu et al. 2004 [65]	165 (63/102)	Age, sex, hyperlipidemia, diabetes,, lesion number and characteristics	RWM	RWM plus Chuan qiong qing	AG	PTCA or stent	6	6	Restenosis, death
Liu et al. 2007 [66]	60 (30/30)	Sex, hypertension, diabetes	RWM	RWM plus Yi qi huo xue fang	AG	PTCA	6	6	Recurrent angina
Lu et al. 2006 [67]	124 (62/62)	Age, sex, hypertension, diabetes, hyperlipidemia, lesion number, location and degree of stenosis, stent number	RWM	RWM plus Xiong shao capsule	AG	Stent	6	6	Restenosis, recurrent angina, AMI, CABG, MLD
Ma et al. 2009 [68]	92 (50/42)	Age, sex, complications, lesion number (narrative only)	RWM	RWM plus Guan mai zai tong	Meeting guide	Stent	3	3	Restenosis
Niu et al. 2003 [69]	36 (18/18)	Baseline patient characteristics (narrative only), hypertension, diabetes, smoking, characteristics and degree of stenosis	RWM	RWM plus Xue yu tong he ji	AG	PTCA or stent	6	6	Restenosis, recurrent angina
Qi et al. 2003 [70]	50 (30/20)	Baseline patient characteristics, lesion number and site (narrative only)	RWM	RWM plus Tong guan capsule	AG	PTCA	6	6	Restenosis, recurrent angina
Qiao et al. 2006 [71]	59 (30/29)	Baseline patient characteristics, hypertension, diabetes, smoking, lesion number and degree of stenosis	RWM plus placebo	RWM plus Tong guan capsule	AG	PTCA	1	1	Quality of life
Shi et al. 1997 [72]	73 (35/38)	Age, sex, hypertension, diabetes, lesion characteristics	RWM	RWM plus Xue fu zhu yu pill	AG	PTCA	6	6	Restenosis, recurrent angina
Wang et al. 2009 [73]	101 (54/47)	Age, sex, course of CAD, degree of blockage, complications	RWM	RWM plus Yi qi huo xue formula	AG	PTCA or stent	3	3	Angina symptoms
Wang et al. 2006 [74]	92 (62/30)	Age, sex, course of CAD (narrative only)	RWM	RWM plus Shan shen tong mai ji	AG	PTCA or stent	1	1	Angina symptoms
Wang et al. 2002 [75]	44 (20/24)	Baseline patient characteristics, CAD course, AG characteristics (narrative only)	RWM	RWM plus Shu xin yin	AG	Stent	6	6	Restenosis, recurrent angina, MI, MACE
Wang et al. 2003 [76]	44 (20/24)	Age, sex, hypertension, diabetes, smoking, AG characteristics	RWM	RWM plus Bu xin yin	AG	Stent	6	6	Restenosis, recurrent angina, AMI, revascularization
Wang and Gao 2004 [77]	94 (41/53)	Age, sex, hypertension, diabetes, smoking, lesion number and type	RWM	RWM plus Yi xin capsule	AG	Stent	6	6	Restenosis, recurrent angina, AMI, revascularization,
Wang et al. 2010 [78]	40 (20/20)	Baseline characteristics similar (narrative only)	RWM	RWM plus Ku lie zhi injection	AG	Stent	6	6	Restenosis, death, AMI
Xiao et al. 2007 [79]	132 (62/70)	Age, sex, hypertension, diabetes, arrhythmia, stent number	RWM	RWM plus Tong xin luo	AG	BMS	6	6	Restenosis, recurrent angina, death, AMI, MACE
Xu et al. 2000 [80]	65 (28/37)	Age, sex, hypertension, diabetes, lesion number and site	RWM	RWM plus Xiong shao capsule	AG	PTCA or stent	6	6	Restenosis, recurrent angina, AMI
Xu et al. 2002 [40]	108 (53/55)	Age, sex, CAD classification	RWM	RWM plus Xiong shao capsule	AG	PTCA or stent	6	6	Restenosis, recurrent angina, AMI, CABG, revascularization
Chen et al. 2006 [81]	314 (157/157)	Age, sex, hypertension, diabetes, lesion number and site	RWM plus placebo	RWM plus Xiong shao capsule	AG	PTCA or stent	6	6	Restenosis, recurrent angina, death, CABG
Yao et al. 2006 [82]	76 (38/38)	Age, sex, lesion number and site	RWM	RWM plus Tong xin luo	AG	PTCA	6	6	Restenosis, recurrent angina, LLS, NG, LANG
Yu et al. 1998 [84]	84 (43/41)	Baseline patient characteristics, hypertension, diabetes, smoking, lesion number and degree of blockage	RWM	RWM plus Xue fu zhu yu pill	AG	Stent	6	6	Restenosis, recurrent angina and accompanying symptoms
Z. A. Yu and S. Y. Yu2006 [85]	82 (42/40)	Age, sex, course of CAD, lesion number and site and degree of blockage	RWM	RWM plus Dan shen tablets	AG	Stent	6	6	Restenosis, recurrent angina, AMI, death
Yi et al. 2005 [83]	40 (20/20)	Age, sex, lesion numbers and sites, history of hypertension and diabetes	RWM	RWM plus Guan tong jian ji	AG	PTCA or stent	6	6	Restenosis, recurrent angina
Zhang et al. 2007 [88]	63 (33/30)	Age, sex, hypertension, diabetes, smoking, lesion site, angina,	RWM	RWM plus Shen mai gua lu shi xiao san	AG	Stent	1	4	Angina symptoms
Zhang et al. 2006 [87]	500 (250/250)	Age, sex, hypertension, diabetes, hyperlipidemia, BMI, degree of blockage (narrative only)	RWM	RWM plus Wen tong jian	AG	PTCA or stent	6	6	Restenosis, recurrent angina
Zhao et al. 2009 [89]	68 (35/33)	Age, sex, hypertension, diabetes, stenosis and lesion diameter of vascular lesion	RWM	RWM plus Shen qi tang	AG	Stent	6	6	Restenosis
Zheng et al. 2004 [86]	66 (36/30)	Baseline patient characteristics, lesion number and characteristics (narrative only)	RWM	RWM plus Fu fang dan shen pill	AG	Stent	6	6	Restenosis, recurrent angina, LLS, NG, LANG
Zhou and Guo 2007 [90]	136 (70/66)	Baseline patient characteristics, lesion characteristics and degree of blockage, stent type (narrative only)	RWM	RWM plus Tong xin luo	AG	Stent	6	6	Restenosis, recurrent angina, AMI, CABG, repeat PCI
Zhu et al. 2009 [91]	138 (70/68)	Age, sex, hypertension, diabetes, hyperlidemia, smoking, lesion number and degree of blockage, stent number	RWM	RWM plus Dan hong tong mai capsule	AG	DES	6	6	Restenosis, recurrent angina, death, AMI, MACE, CABG, repeat PCI

AG = angiography; BMI = body mass index; BMS = bare metal stent; CABG = coronary artery bypass graft; CAD = coronary artery disease; DES = drug eluting stent; LANG = lesion area net gain; LLL = late loss of lumen; MLD = minimum lumen diameter; NG = net gain in lumen diameter; PCI = percutaneous coronary intervention; PTCA = percutaneous transluminal coronary angioplasty; RWM = routine Western medicine; T/C = treatment/control; TCM = traditional Chinese medicine.