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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 254960, 13 pages
http://dx.doi.org/10.1155/2012/254960
Research Article

Solanum lyratum Extracts Induce Extrinsic and Intrinsic Pathways of Apoptosis in WEHI-3 Murine Leukemia Cells and Inhibit Allograft Tumor

1Department of Pharmacology, China Medical University, Taichung 404, Taiwan
2Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan
3School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
4School of Pharmacy, China Medical University, Taichung 404, Taiwan
5Department of Urology, China Medical University Hospital, Taichung 404, Taiwan
6Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan
7Department of Pharmacology, School of Medicine, Geriatric Research, Education and Clinical Center, VA Medical Center, University of Minnesota, Minneapolis, MN 55455, USA
8Department of Biochemistry, Nihon Pharmaceutical University, Saitama 362-0806, Japan
9Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
10Department of Biotechnology, Asia University, Taichung 413, Taiwan

Received 28 September 2011; Revised 8 January 2012; Accepted 16 February 2012

Academic Editor: Cheppail Ramachandran

Copyright © 2012 Jai-Sing Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. P. Lin, J. S. Yang, J. J. Lin et al., “Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo,” Environmental Toxicology, vol. 13, no. 4, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Sack, “Leukemia in patients with breast carcinoma after adjuvant chemotherapy and/or postoperative radiotherapy,” Strahlentherapie Und Onkologie, vol. 171, no. 7, pp. 420–421, 1995. View at Google Scholar · View at Scopus
  3. D. R. Green and J. C. Reed, “Mitochondria and apoptosis,” Science, vol. 281, no. 5381, pp. 1309–1312, 1998. View at Google Scholar · View at Scopus
  4. S. J. Riedl and G. S. Salvesen, “The apoptosome: signalling platform of cell death,” Nature Reviews Molecular Cell Biology, vol. 8, no. 5, pp. 405–413, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. J. F. Kerr, A. H. Wyllie, and A. R. Currie, “Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics,” British Journal of Cancer, vol. 26, no. 4, pp. 239–257, 1972. View at Google Scholar · View at Scopus
  6. K. M. Debatin, “Apoptosis pathways in cancer and cancer therapy,” Cancer Immunology, Immunotherapy, vol. 53, no. 3, pp. 153–159, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Zheng, Z. Zhang, X. Lv et al., “Polycystin-1 induced apoptosis and cell cycle arrest in g0/g1 phase in cancer cells,” Cell Biology International, vol. 32, no. 4, pp. 427–435, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Yano, A. Mizoguchi, K. Fukuda et al., “The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase,” Cancer Research, vol. 54, no. 2, pp. 448–454, 1994. View at Google Scholar · View at Scopus
  9. J. Y. Liu, M. J. Lee, H. M. Chen et al., “Ocimum gratissimum aqueous extract protects h9c2 myocardiac cells from H2o2-induced cell apoptosis through akt signalling,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 578060, 8 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Robbins, X. Gu, R. Shi et al., “The chemopreventive effects of protandim: modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis,” Plos One, vol. 5, no. 7, Article ID e11902, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Evan and T. Littlewood, “A matter of life and cell death,” Science, vol. 281, no. 5381, pp. 1317–1322, 1998. View at Google Scholar · View at Scopus
  12. W. Yalin, P. Yuanjiang, and S. Cuirong, “Isolation, purification and structural investigation of a water-soluble polysaccharide from Solanum lyratum thunb,” International Journal of Biological Macromolecules, vol. 36, no. 4, pp. 241–245, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. B. Kang, E. Lee, I. Hong, J. Lee, and H. Kim, “Abolition of anaphylactic shock by Solanum lyratum thunb,” International Journal of Immunopharmacology, vol. 19, no. 11-12, pp. 729–734, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. J. S. Yang, C. C. Wu, C. L. Kuo et al., “Solannm lyratum extract affected immune response in normal and leukemia murine animal in vivo,” Human and Experimental Toxicology, vol. 29, no. 5, pp. 359–367, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. L. X. Sun, W. W. Fu, W. Li, K. S. Bi, and M. W. Wang, “Diosgenin glucuronides from Solanum lyratum and their cytotoxicity against tumor cell lines,” Zeitschrift Fur Naturforschung. C, vol. 61, no. 3-4, pp. 171–176, 2006. View at Google Scholar · View at Scopus
  16. J. Ren, G. N. Feng, M. W. Wang, and L. X. Sun, “Primary study on the anti-tumor effect of ethanol extracts of Solanum lyratum,” China Journal of Chinese Materia Medica, vol. 31, no. 6, pp. 497–500, 2006. View at Google Scholar
  17. L. X. Sun, W. W. Fu, J. Ren, L. Xu, K. S. Bi, and M. W. Wang, “Cytotoxic constituents from Solanum lyratum,” Archives of Pharmacal Research, vol. 29, no. 2, pp. 135–139, 2006. View at Google Scholar · View at Scopus
  18. X. Wei, C. G. Li, S. Nong, X. Y. Zhu, and X. M. Huang, “The influence of Solanum lyratum thunb extract on apoptosis and the expression of fas/fasl genes in hela cells,” Zhong Yao Cai, vol. 29, no. 11, pp. 1203–1206, 2006. View at Google Scholar · View at Scopus
  19. C. M. Shan and J. Li, “Study of apoptosis in human liver cancers,” World Journal of Gastroenterology, vol. 8, no. 2, pp. 247–252, 2002. View at Google Scholar · View at Scopus
  20. S. Q. Gu, Y. Y. Liang, L. R. Fan et al., “Co-regulative effects of the cAMP/PKA and DAG/PKC signal pathways on human gastric cancer cells during differentiation induced by traditional Chinese medicines,” World Journal of Gastroenterology, vol. 3, no. 1, pp. 50–53, 1997. View at Google Scholar
  21. S. C. Hsu, J. H. Lu, C. L. Kuo et al., “Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (colo 205),” Anticancer Research, vol. 28, no. 2 A, pp. 1045–1054, 2008. View at Google Scholar · View at Scopus
  22. J. H. Lee, Y. H. Lee, H. J. Lee et al., “Caspase and mitogen activated protein kinase pathways are involved in Solanum lyratum herba induced apoptosis,” Journal of Ethnopharmacology, vol. 123, no. 1, pp. 121–127, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Yang, F. Feng, and Y. Gao, “Chemical constituents from herb of Solanum lyratum,” Zhongguo Zhongyao Zazhi, vol. 34, no. 14, pp. 1805–1808, 2009. View at Google Scholar · View at Scopus
  24. R. M. Zucker, K. H. Elstein, R. E. Easterling, and E. J. Massaro, “Flow cytometric comparison of the effects of trialkyltins on the murine erythroleukemic cell,” Toxicology, vol. 58, no. 2, pp. 107–119, 1989. View at Google Scholar · View at Scopus
  25. C. C. Lu, J. S. Yang, A. C. Huang et al., “Chrysophanol induces necrosis through the production of ros and alteration of atp levels in j5 human liver cancer cells,” Molecular Nutrition and Food Research, vol. 54, no. 7, pp. 967–976, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. J. H. Chiang, J. S. Yang, C. Y. Ma et al., “Danthron, an anthraquinone derivative, induces dna damage and caspase cascades-mediated apoptosis in snu-1 human gastric cancer cells through mitochondrial permeability transition pores and bax-triggered pathways,” Chemical Research in Toxicology, vol. 24, no. 1, pp. 20–29, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. I. Nicoletti, G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi, “A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry,” Journal of Immunological Methods, vol. 139, no. 2, pp. 271–279, 1991. View at Publisher · View at Google Scholar · View at Scopus
  28. S. H. Wu, L. W. Hang, J. S. Yang et al., “Curcumin induces apoptosis in human non-small cell lung cancer nci-h460 cells through er stress and caspase cascade- and mitochondria-dependent pathways,” Anticancer Research, vol. 30, no. 6, pp. 2125–2133, 2010. View at Google Scholar · View at Scopus
  29. J. G. Chung, J. S. Yang, L. J. Huang et al., “Proteomic approach to studying the cytotoxicity of yc-1 on u937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice,” Proteomics, vol. 7, no. 18, pp. 3305–3317, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Kobara, N. Sunagawa, M. Abe et al., “Apoptotic myocytes generate monocyte chemoattractant protein-1 and mediate macrophage recruitment,” Journal of Applied Physiology, vol. 104, no. 3, pp. 601–609, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. W. W. Huang, J. S. Yang, C. F. Lin, W. J. Ho, and M. R. Lee, “Pycnogenol induces differentiation and apoptosis in human promyeloid leukemia hl-60 cells,” Leukemia Research, vol. 29, no. 6, pp. 685–692, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. X. Chen, P. Lv, J. Liu, and K. Xu, “Apoptosis of human hepatocellular carcinoma cell (hepg2) induced by cardiotoxin iii through s-phase arrest,” Experimental and Toxicologic Pathology, vol. 61, no. 4, pp. 307–315, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Müller, S. Strand, H. Hug et al., “Drug-induced apoptosis in hepatoma cells is mediated by the cd95 (APO- 1/FAS) receptor/ligand system and involves activation of wild-type p53,” Journal of Clinical Investigation, vol. 99, no. 3, pp. 403–413, 1997. View at Google Scholar · View at Scopus
  34. J. A. Houghton, F. G. Harwood, and D. M. Tillman, “Thymineless death in colon carcinoma cells is mediated via fas signaling,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 15, pp. 8144–8149, 1997. View at Publisher · View at Google Scholar · View at Scopus
  35. Y. C. Li, H. J. Lin, J. H. Yang et al., “Baicalein-induced apoptosis via endoplasmic reticulum stress through elevations of reactive oxygen species and mitochondria dependent pathway in mouse-rat hybrid retina ganglion cells (n18),” Neurochemical Research, vol. 34, no. 3, pp. 418–429, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. F. S. Yu, J. S. Yang, C. S. Yu et al., “Safrole induces apoptosis in human oral cancer hsc-3 cells,” Journal of Dental Research, vol. 90, no. 2, pp. 168–174, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. J. S. Yang, G. W. Chen, T. C. Hsia et al., “Diallyl disulfide induces apoptosis in human colon cancer cell line (colo 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways,” Food and Chemical Toxicology, vol. 47, no. 1, pp. 171–179, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. T. Dai, H. Zheng, and G. S. Fu, “Full-length article hypoxia confers protection against apoptosis via the pi3k/akt pathway in endothelial progenitor cells,” Acta Pharmacologica Sinica, vol. 29, no. 12, pp. 1425–1431, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. J. S. Yang, M. J. Hour, W. W. Huang, K. L. Lin, S. C. Kuo, and J. G. Chung, “Mj-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated bcl-2 phosphorylation in human leukemia u937 cells,” Journal of Pharmacology and Experimental Therapeutics, vol. 334, no. 2, pp. 477–488, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. P. P. Wu, K. C. Liu, W. W. Huang et al., “Diallyl trisulfide (dats) inhibits mouse colon tumor in mouse ct-26 cells allograft model in vivo,” Phytomedicine, vol. 18, no. 8-9, pp. 672–676, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. L. C. Chou, J. S. Yang, L. J. Huang et al., “The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (chm-1) promoted g2/m arrest through inhibition of cdk1 and induced apoptosis through the mitochondrial-dependent pathway in ct-26 murine colorectal adenocarcinoma cells,” Journal of Gastroenterology, vol. 44, no. 10, pp. 1055–1063, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. D. Dilloo, M. Brown, M. Roskrow et al., “Cd40 ligand induces an antileukemia immune response in vivo,” Blood, vol. 90, no. 5, pp. 1927–1933, 1997. View at Google Scholar · View at Scopus
  43. S. Haupt, M. Berger, Z. Goldberg, and Y. Haupt, “Apoptosis—the p53 network,” Journal of Cell Science, vol. 116, no. 20, pp. 4077–4085, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Bates and K. H. Vousden, “Mechanisms of p53-mediated apoptosis,” Cellular and Molecular Life Sciences, vol. 55, no. 1, pp. 28–37, 1999. View at Publisher · View at Google Scholar · View at Scopus
  45. N. A. Liu, H. Jiang, A. Ben-Shlomo et al., “Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (cdk) inhibitor,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 20, pp. 8414–8419, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Mihara, S. Shintani, K. I. Nakashiro, and H. Hamakawa, “Flavopiridol, a cyclin dependent kinase (cdk) inhibitor, induces apoptosis by regulating bcl-x in oral cancer cells,” Oral Oncology, vol. 39, no. 1, pp. 49–55, 2003. View at Publisher · View at Google Scholar · View at Scopus
  47. T. Hunter and J. Pines, “Cyclins and cancer ii: cyclin d and cdk inhibitors come of age,” Cell, vol. 79, no. 4, pp. 573–582, 1994. View at Publisher · View at Google Scholar · View at Scopus
  48. P. May and E. May, “Twenty years of p53 research: structural and functional aspects of the p53 protein,” Oncogene, vol. 18, no. 53, pp. 7621–7636, 1999. View at Google Scholar · View at Scopus
  49. S. Srinivasan, S. Koduru, R. Kumar, G. Venguswamy, N. Kyprianou, and C. Damodaran, “Diosgenin targets akt-mediated prosurvival signaling in human breast cancer cells,” International Journal of Cancer, vol. 125, no. 4, pp. 961–967, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. G. M. Cohen, “Caspases: the executioners of apoptosis,” Biochemical Journal, vol. 326, no. 1, pp. 1–16, 1997. View at Google Scholar · View at Scopus
  51. J. C. Chen, K. W. Lu, M. L. Tsai et al., “Gypenosides induced g0/g1 arrest via chk2 and apoptosis through endoplasmic reticulum stress and mitochondria-dependent pathways in human tongue cancer scc-4 cells,” Oral Oncology, vol. 45, no. 3, pp. 273–283, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. J. Raju and R. Mehta, “Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin,” Nutrition and Cancer, vol. 61, no. 1, pp. 27–35, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. C. Cailleteau, B. Liagre, and J. L. Beneytout, “A proteomic approach to the identification of molecular targets in subsequent apoptosis of hel cells after diosgenin-induced megakaryocytic differentiation,” Journal of Cellular Biochemistry, vol. 107, no. 4, pp. 785–796, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. D. Bian, Z. Li, H. Ma et al., “Effects of diosgenin on cell proliferation induced by igf-1 in primary human thyrocytes,” Archives of Pharmacal Research, vol. 34, no. 6, pp. 997–1005, 2011. View at Publisher · View at Google Scholar · View at Scopus