Research Article
Dose-Dependent Effects of the Cimicifuga racemosa Extract Ze 450 in the Treatment of Climacteric Complaints: A Randomized, Placebo-Controlled Study
Table 1
Demographic details: mean (SD), ITT population.
| | n | Placebo | n | Low dose | n | High dose | P value1 |
| Age (years) | 54 | 50.5 (7.0) | 57 | 52.0 (6.3) | 55 | 52.8 (6.0) | 0.168 | Weight (kg) | 54 | 67.7 (11.6) | 57 | 70.5 (13.0) | 55 | 68.3 (12.2) | 0.433 | BMI (kg/m2) | 54 | 24.9 (4.3) | 57 | 25.6 (5.1) | 55 | 25.0 (3.9) | 0.634 | Height (cm) | 54 | 164.9 (5.1) | 57 | 166.3 (7.1) | 55 | 165.2 (7.4) | 0.537 | KMI (points) | 54 | 27.3 (6.5) | 57 | 28.1 (6.9) | 55 | 28.4 (8.0) | 0.692 | QoL (mm) | 54 | 37.2 (15.6) | 57 | 31.2 (15.9) | 55 | 34.7 (17.6) | 0.150 | Premenopausal (n) | 54 | 15 | 57 | 12 | 55 | 11 | 0.8032 | Early postmenopausal (n) | 54 | 27 | 57 | 28 | 55 | 30 | Late postmenopausal (n) | 54 | 12 | 57 | 17 | 55 | 14 | Baseline FSH ≤ 40 mIU/mL (n) | 54 | 21 | 57 | 22 | 55 | 15 | 0.3332 | Baseline FSH > 40 mIU/mL (n) | 54 | 22 | 57 | 26 | 55 | 33 | Baseline FSH unknown | 54 | 11 | 57 | 9 | 55 | 7 | Baseline KMI ≤ 20 | 54 | 9 | 57 | 10 | 55 | 10 | 0.4542 | Baseline KMI 21–35 | 54 | 36 | 57 | 41 | 55 | 32 | Baseline KMI > 35 | 54 | 9 | 57 | 6 | 55 | 13 | Nonsmoker (n) | 54 | 41 | 57 | 44 | 55 | 39 | 0.5753 | Occasional smoker (n) | 54 | 3 | 57 | 0 | 55 | 4 | Moderate smoker (n) | 54 | 6 | 57 | 7 | 55 | 7 | Heavy smoker (n) | 54 | 4 | 57 | 6 | 55 | 5 |
|
|
nalysis of variance, 2Chi-square test, 3Fisher’s exact test.
|