Oreocnide integrifolia Flavonoids Augment Reprogramming for Islet Neogenesis and β-Cell Regeneration in Pancreatectomized BALB/c Mice

Figure 3

(a)–(c) Images represent insulin/BrdU immunostained confocal sections of pancreas from pancreatectomized mice at day 7, 14 and 21, respectively, and (d)–(f) Px + FRF-treated mice at day 7, 14, and 21, respectively. Scale bar represents 50 μm. (g) Quantitative BrdU incorporation within islets with varying size. All values are expressed as mean + SEM of six animals (one-way ANOVA), where, ^•𝑃<0.05, ^■𝑃<0.01, ^♦𝑃<0.001: sham was compared to other experimental groups; white numbered 1 circle 𝑃<0.05: Px day 14 was compared to Px day 14 + FRF; black numbered 1 circle 𝑃<0.05: Px day 21 was compared to Px day 21 + FRF.