Research Article
Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in Balb/C Mice
Table 2
Histologic scoring system for DSS-induced colitis.
| Scoring of severity of histological damage | Feature | Score | Description |
| Severity of inflammation | 0 | None | 1 | Mild | 2 | Moderate | 3 | Severe |
| Extent of inflammation | 0 | None | 1 | Mucosa | 2 | Mucosa and submucosa | 3 | Transmural |
| Crypt damage | 0 | None | 1 | 1/3 damaged | 2 | 2/3 damaged | 3 | Crypts lost, surface epithelium present | 4 | Crypts lost and surface epithelium lost |
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**Scores were calculated by adding the score for the three parameters, giving a maximum score of 10.
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