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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 278652, 12 pages
Research Article

The Cytotoxicity Mechanism of 6-Shogaol-Treated HeLa Human Cervical Cancer Cells Revealed by Label-Free Shotgun Proteomics and Bioinformatics Analysis

State Key Laboratory of Natural Medicines, Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210009, China

Received 26 July 2012; Revised 24 September 2012; Accepted 1 October 2012

Academic Editor: Shrikant Anant

Copyright © 2012 Qun Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [14 citations]

The following is the list of published articles that have cited the current article.

  • Regi Jose, G. R. Sajitha, and K. T. Augusti, “A Review on the Role of Nutraceuticals as Simple as Se2+ to Complex Organic Molecules Such as Glycyrrhizin That Prevent as Well as Cure Diseases,” Indian Journal of Clinical Biochemistry, 2013. View at Publisher · View at Google Scholar
  • Qun Liu, Yong-Bo Peng, Ping Zhou, Lian-Wen Qi, Mu Zhang, Ning Gao, E-Hu Liu, and Ping Li, “6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2 alpha,” Molecular Cancer, vol. 12, 2013. View at Publisher · View at Google Scholar
  • Chun Yao, Hongqin Zhuang, Pan Du, Wei Cheng, Bingya Yang, Shengwen Guan, Yun Hu, Dalong Zhu, Miller Christine, Lv Shi, and Zi-Chun Hua, “Role of Fas-Associated Death Domain-containing Protein (FADD) Phosphorylation in Regulating Glucose Homeostasis: from Proteomic Discovery to Physiological Validation,” Molecular & Cellular Proteomics, vol. 12, no. 10, pp. 2689–2700, 2013. View at Publisher · View at Google Scholar
  • Alan Soo-Beng Khoo, Mallikarjuna Rao Pichika, Kai Hung Tiong, Chee-Onn Leong, Boon Shing Tan, Owen Kang, Chun Wai Mai, and Tracey D. Bradshaw, “6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor gamma (PPAR gamma),” Cancer Letters, vol. 336, no. 1, pp. 127–139, 2013. View at Publisher · View at Google Scholar
  • Joydeb Kumar Kundu, Zae Young Ryoo, Ann M. Bode, Young-Joon Surh, Zigang Dong, Myoung Ok Kim, Mee-Hyun Lee, Naomi Oi, Sung-Hyun Kim, Ki Beom Bae, Zunnan Huang, Dong Joon Kim, Kanamata Reddy, Sung-Young Lee, Si Jun Park, Jae Young Kim, and Hua Xie, “[6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2,” Carcinogenesis, vol. 35, no. 3, pp. 683–691, 2014. View at Publisher · View at Google Scholar
  • Ling Zhou, Lianwen Qi, Lifeng Jiang, Ping Zhou, Jiang Ma, Xiaojun Xu, and Ping Li, “Antitumor Activity of Gemcitabine Can Be Potentiated in Pancreatic Cancer through Modulation of TLR4/NF-kappa B signaling by 6-Shogaol,” Aaps Journal, vol. 16, no. 2, pp. 246–257, 2014. View at Publisher · View at Google Scholar
  • Ali Ghasemzadeh, Hawa Z.E. Jaafar, and Asmah Rahmat, “Optimization protocol for the extraction of 6-gingerol and 6-shogaol from Zingiber officinale var. rubrum Theilade and improving antioxidant and anticancer activity using response surface methodology,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, 2015. View at Publisher · View at Google Scholar
  • Wenwen Zhang, Qi Shen, Miaomiao Chen, Ying Wang, Qingfeng Zhou, Xuejiao Tao, and Xueqiong Zhu, “The role of 14-3-3 proteins in gynecological tumors,” Frontiers In Bioscience-Landmark, vol. 20, pp. 934–945, 2015. View at Publisher · View at Google Scholar
  • Shipra Bhargava, Hemant Malhotra, Om Singh Rathore, Bharti Malhotra, Pratibha Sharma, Amla Batra, Asha Sharma, and Shubhada V. Chiplunkar, “Anti-leukemic activities of alcoholic extracts of two traditional Indian medicinal plants,” Leukemia & Lymphoma, pp. 1–15, 2015. View at Publisher · View at Google Scholar
  • Miho Akimoto, Mari Iizuka, Rie Kanematsu, Masato Yoshida, and Keizo Takenaga, “Anticancer effect of ginger extract against pancreatic cancer cells mainly through reactive oxygen species-mediated autotic cell death,” PLoS ONE, vol. 10, no. 5, 2015. View at Publisher · View at Google Scholar
  • Chong-Zhi Wang, Lian-Wen Qi, and Chun-Su Yuan, “Cancer Chemoprevention Effects of Ginger and its Active Constituents: Potential for New Drug Discovery,” American Journal Of Chinese Medicine, vol. 43, no. 7, pp. 1351–1363, 2015. View at Publisher · View at Google Scholar
  • Georgia Kontostathi, Jerome Zoidakis, Nicholas P. Anagnou, Kalliopi I. Pappa, Antonia Vlahou, and Manousos Makridakis, “Proteomics approaches in cervical cancer: focus on the discovery of biomarkers for diagnosis and drug treatment monitoring,” Expert Review of Proteomics, vol. 13, no. 8, pp. 731–745, 2016. View at Publisher · View at Google Scholar
  • Roghiyeh Pashaei-Asl, Fatima Pashaei-Asl, Parvin Mostafa Gharabaghi, Khodadad Khodadadi, Mansour Ebrahimi, Esmaeil Ebrahimie, and Maryam Pashaiasl, “The Inhibitory Effect of Ginger Extract on Ovarian Cancer Cell Line; Application of Systems Biology,” Advanced Pharmaceutical Bulletin, vol. 7, no. 2, pp. 241–249, 2017. View at Publisher · View at Google Scholar
  • Alessandra Vidotto, Ana T. S. Morais, Milene Rocha Ribeiro, Carolina C. Pacca, Ana C. B. Terzian, Laura H. V. G. Gil, Ronaldo Mohana-Borges, Philippe Gallay, and Mauricio L Nogueira, “Systems Biology reveals NS4B-Cyclophilin A interaction: a new target to inhibit YFV replication,” Journal of Proteome Research, 2017. View at Publisher · View at Google Scholar