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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 278718, 11 pages
http://dx.doi.org/10.1155/2012/278718
Research Article

Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis

1Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 540-749, Republic of Korea
2Department of Manufacturing Convergence Technology, Korean Institute of Industrial Technology, 1271-18, Sa-3 dong, Sangrok-gu, Ansan city, Gyeonggi-do 426-173, Republic of Korea
3ChungBuk Technopark Bio Center, Jecheon, ChungBuk 390-250, Republic of Korea
4Jeollanamdo Development Institute for Korean Traditional Medicine, Jangheung, Jeollanamdo 529-851, Republic of Korea
5Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea
6Department of Internal Medicine, College of Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea

Received 3 March 2011; Revised 30 May 2011; Accepted 30 May 2011

Academic Editor: José Luis Ríos

Copyright © 2012 Min-Sun Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myrrh has been used as an antibacterial and anti-inflammatory agent. However, effect of myrrh on peritoneal macrophages and clinically relevant models of septic shock, such as cecal ligation and puncture (CLP), is not well understood. Here, we investigated the inhibitory effect and mechanism(s) of myrrh on inflammatory responses. Myrrh inhibited LPS-induced productions of inflammatory mediators such as nitric oxide, prostaglandin E2, and tumor necrosis factor-α but not of interleukin (IL)-1β and IL-6 in peritoneal macrophages. In addition, Myrrh inhibited LPS-induced activation of c-jun NH2-terminal kinase (JNK) but not of extracellular signal-regulated kinase (ERK), p38, and nuclear factor-κB. Administration of Myrrh reduced the CLP-induced mortality and bacterial counts and inhibited inflammatory mediators. Furthermore, administration of Myrrh attenuated CLP-induced liver damages, which were mainly evidenced by decreased infiltration of leukocytes and aspartate aminotransferase/alanine aminotransferase level. Taken together, these results provide the evidence for the anti-inflammatory and antibacterial potential of Myrrh in sepsis.