Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis
Effects of myrrh on CLP-induced sepsis. Myrrh (0.1 g/kg or 0.2 g/kg) was administrated intraperitoneally 1 h before CLP. The blood and peritoneal fluids were harvested for measuring leukocyte accumulation and bacterial clearance at 24 h after CLP. (a) The survival rate was monitored every day for 8 d, and each group contained 20 mice. (b) Leukocyte accumulation to peritoneal lavage fluids was measured by Diff Quick staining and (c) bacterial clearance was measured in blood and peritoneal lavage fluids. To examine cytokine production, the blood and peritoneal lavage fluids were obtained 6 h after CLP. The cytokine expression in (d) serum and (e) peritoneal lavage fluid were measured by ELISA. The values are means ± SD of three independent experiments. * versus CLP.