Traditional Herbal Medicine, Rikkunshito, Induces HSP60 and Enhances Cytoprotection of Small Intestinal Mucosal Cells as a Nontoxic Chaperone Inducer

Figure 2

Antinecrotic ability. Hydrogen peroxide-(a) or Indomethacin-(c) induced cell necrosis was significantly suppressed in IEC-6 cells pretreated with TJ-43 compared with nontreated IEC-6 cells under necrotic condition based on MTT assay. Cytotoxicity, based on LDH-release after hydrogen peroxide- (b) or indomethacin- (d) treatment was also significantly reduced in TJ-43 pretreated IEC-6 cells compared with nontreated IEC-6 cells (control cells). Values are means ± SEM. *𝑃<0.05, **𝑃<0.01 compared with control cells.

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