The Chinese Herbal Decoction Danggui Buxue Tang Inhibits Angiogenesis in a Rat Model of Liver Fibrosis
Effects of DBT and NAC on liver fibrosis induced by CCl4. (a) Sirius red staining of collagen deposition in liver fibrosis. CCl4 induced an increase in liver collagen. DBT and NAC decreased the collagen deposition in the fibrotic liver tissue. (b) Immunohistochemical staining of type I collagen protein expression in liver tissue (DAB). The model group had much stronger and more extensive positive staining among fibrotic septa compared with the normal group. DBT and NAC significantly decreased the amount of positive staining. (c) Liver Hyp content was determined using Jamall’s method. The Hyp content was increased significantly in the model group compared with the normal group. DBT and NAC treatment significantly decreased liver Hyp content. versus normal group, versus model group.