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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 298925, 6 pages
http://dx.doi.org/10.1155/2012/298925
Research Article

Interleukin-10 Genotype Correlated to Deficiency Syndrome in Hepatitis B Cirrhosis

1Research Center for TCM Complexity System, Shanghai University of TCM, Shanghai 201203, China
2Henan University of TCM, Zhengzhou, Henan 450008, China
3Ruikang Hospital of Guangxi University of TCM, Nanning, Guangxi 530011, China
4Longhua Hospital, Shanghai 200126, China
5Shuguang Hospital, Shanghai 200021, China
6Yueyang Hospital, Shanghai 200437, China
7Putuo Hospital, Shanghai 200060, China

Received 13 February 2012; Accepted 28 March 2012

Academic Editor: Shao Li

Copyright © 2012 Qing-Ya Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Traditional Chinese medicine (TCM) syndrome is an important basis for TCM diagnosis and treatment. As Child-Pugh classification as well as compensation and decompensation phase in liver cirrhosis, it is also an underlying clinical classification. In this paper, we investigated the correlation between single nucleotide polymorphisms (SNPs) of Interleukin-10 (IL-10) and TCM syndromes in patients with hepatitis B cirrhosis (HBC). Samples were obtained from 343 HBC patients in China. Three SNPs of IL-10 (−592A/C, −819C/T, and −1082A/G) were detected with polymerase chain-reaction-ligase detection reaction (PCR-LDR). The result showed the SNP-819C/T was significantly correlated with Deficiency syndrome ( ), but none of the 3 loci showed correlation either with Child-Pugh classification and phase in HBC patients. The logistic regression analysis showed that the Excess syndrome was associated with dizzy and spider nevus, and the Deficiency syndrome was associated with dry eyes, aversion to cold, IL-10-819C/T loci, and IL-10-1082A/G loci. The odds ratio (OR) value at IL-10-819C/T was 4.022. The research results suggested that IL-10-819C/T locus (TC plus CC genotype) is probably a risk factor in the occurrence of Deficiency syndrome in HBC patients.