Intestinal, Airway, and Cardiovascular Relaxant Activities of Thymoquinone

Figure 6

Inhibitory effect of thymoquinone (TQ) on acetylcholine-(ACh, 10 𝜇M) induced reduction in airway diameter in mouse lung slices. (a) and (b) show the effect of ACh, alone (top, a) and in presence (b) of TQ (100 𝜇M), on airway diameter shown as a line scan of a single lung airway. Subfigure (c) shows pooled data for the contractile effect of ACh on airway diameter in the absence (control) and presence of TQ 10 𝜇M (𝑛=6), TQ 100 𝜇M (𝑛=5), verapamil 1 𝜇M (Verap; 𝑛=4), and verapamil 10 𝜇M (Verap; 𝑛=4). Values shown are mean ± SEM; ^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001, and ^#𝑃>0.05; one-way ANOVA followed by Tukey’s Multiple Comparison test.

(a)

(b)

(c)