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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 324039, 7 pages
Research Article

Effects of Electroacupuncture at BL60 on Formalin-Induced Pain in Rats

1Department of Physiology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea
2Division of Health Science, Department of Biomedical Laboratory Science, Dongseo University, Busan 617-716, Republic of Korea
3Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul 130-701, Republic of Korea

Received 1 June 2011; Revised 23 November 2011; Accepted 23 December 2011

Academic Editor: Fengxia Liang

Copyright © 2012 Kyung-Ha Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acupuncture was used to treat symptoms of pain in the ancient orient. The present study was conducted to determine the effects of electroacupuncture (EA) at the BL60 acupoint on male Sprague-Dawley rats. Each rat received EA at BL60 acupoint before formalin injection. Behavioral responses were recorded using a video camera and c-Fos immunohistochemistry was performed thereafter. Treatment of EA at BL60 significantly inhibited flinching behavior and c-fos expression induced by formalin injection into the paw, compared to a control group. These results suggest that electroacupuncture at BL60 acupoint may be effective in relieving inflammatory pain.