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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 340141, 9 pages
http://dx.doi.org/10.1155/2012/340141
Research Article

Analgesic and Anti-Inflammatory Activities of Methanol Extract of Ficus pumila L. in Mice

1School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
2Department of Nursing, Hsin Sheng College of Medical Care and Management, Taoyuan 325, Taiwan
3Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan
4Department of Nursing, Hungkuang University, Sha Lu, Taichung 433, Taiwan

Received 15 November 2011; Revised 29 February 2012; Accepted 29 February 2012

Academic Editor: William C. S. Cho

Copyright © 2012 Chi-Ren Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study investigated possible analgesic and anti-inflammatory mechanisms of the methanol extract of Ficus pumila ( ). Analgesic effects were evaluated in two models including acetic acid-induced writhing response and formalin-induced paw licking. The results showed decreased writhing response in the acetic acid assay and licking time in the formalin test. The anti-inflammatory effect was evaluated by λ-carrageenan-induced mouse paw edema and histopathological analyses. significantly decreased the volume of paw edema induced by λ-carrageenan. Histopathologically, abated the level of tissue destruction and swelling of the edema paws. This study indicated anti-inflammatory mechanism of may be due to declined levels of NO and MDA in the edema paw through increasing the activities of SOD, GPx, and GRd in the liver. Additionally, also decreased the level of inflammatory mediators such as IL-1β, TNF-α, and COX-2. HPLC fingerprint was established and the contents of three active ingredients, rutin, luteolin, and apigenin, were quantitatively determined. This study provided evidence for the classical treatment of Ficus pumila in inflammatory diseases.