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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 350125, 8 pages
http://dx.doi.org/10.1155/2012/350125
Research Article

55-Week Treatment of Mice with the Unani and Ayurvedic Medicine Pomegranate Flower Ameliorates Ageing-Associated Insulin Resistance and Skin Abnormalities

1Division of Metabolism, Faculty of Basic Medical Sciences, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, China
2Department of Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
3Disease State Management Group, Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia
4Pharmafood Institute, Kyoto 602-8136, Japan
5Endocrinology and Metabolism Group, Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia

Received 14 August 2011; Revised 22 September 2011; Accepted 29 September 2011

Academic Editor: Yoshiyuki Kimura

Copyright © 2012 Jianwei Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

PPARs play a pivotal role in regulating lipid and glucose homeostasis and are involved in diverse biological activities in skin. Pomegranate flower (PGF, an antidiabetic therapy in Unani and Ayurvedic medicines) has been previously demonstrated to activate both PPARalpha/gamma. Here, we found that treatment of mice with the diet containing PGF powder over 55 weeks attenuated ageing-induced abnormal increases in the homeostasis model assessment of insulin resistance, glucose concentrations during oral glucose tolerance test, and adipose insulin resistance index. The diet tended to decrease the excessive peri-ovary fat mass. It, however, increased the thinned subcutaneous fat thickness. In addition, the diet restored decreases in skin water content, epidermis thickness, and collagen density in corium. Thus, our results demonstrate that long-term treatment with the Unani and Ayurvedic therapy ameliorates ageing-induced insulin resistance, which is associated with reversal of ageing-induced fat redistribution. Further, PGF attenuates ageing-mediated undesirable skin abnormalities.