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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 364741, 8 pages
Research Article

Triterpenoid-Rich Extract from Antrodia camphorata Improves Physical Fatigue and Exercise Performance in Mice

1Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan
2Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
3Dong Jyu Biotechnology Corporation, Taipei 10683, Taiwan, Taiwan
4Graduate Institute of Athletics and Coaching Science, National Taiwan Sport University, Taoyuan 33301, Taiwan

Received 14 March 2012; Accepted 30 May 2012

Academic Editor: Cheorl-Ho Kim

Copyright © 2012 Chi-Chang Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Antrodia camphorata (AC) is an endemic mushroom that grows in Taiwan. We investigated the fatigue-alleviating effects of AC on endurance capacity in swim-exercised and weight-loading mice. Male Institute of Cancer Research (ICR) strain mice from 3 groups ( per group in each test) were orally administered AC fruiting body extract for 7 days at 0, 50, and 200 mg/kg/day, designated vehicle, AC-50, and AC-200, respectively. Trend analysis revealed that AC treatments increased grip strength. AC dose-dependently increased swim time, blood glucose, and muscular and hepatic glycogen levels and dose-dependently decreased plasma lactate and ammonia levels and creatine kinase activity. The increase in swimming endurance with AC administration was caused by an increase in liver and muscle glycogen deposition. A. camphorata may have potential for use in ergogenic and antifatigue activities.