Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 385247, 11 pages
http://dx.doi.org/10.1155/2012/385247
Research Article

Effects of Buyang Huanwu Decoction on Ventricular Remodeling and Differential Protein Profile in a Rat Model of Myocardial Infarction

1Nanfang Hospital, Southern Medical University, Guangdong, Guangzhou 510515, China
2The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangdong, Guangzhou 510515, China
3Yuebei People’s Hospital, Guangdong, Shaoguan 512026, China

Received 7 April 2012; Revised 5 July 2012; Accepted 25 July 2012

Academic Editor: Haruki Yamada

Copyright © 2012 Ying Chun Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Lloyd-Jones, R. J. Adams, T. M. Brown et al., “Heart disease and stroke statistics-2010 update: a report from the american heart association,” Circulation, vol. 121, no. 7, pp. e46–e215, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. J. E. Udelson and M. A. Konstam, “Relation between left ventricular remodeling and clinical outcomes in heart failure patients with left ventricular systolic dysfunction,” Journal of Cardiac Failure, vol. 8, no. 6, supplement, pp. S465–S471, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. J. E. Udelson, R. D. Patten, and M. A. Konstam, “New concepts in post-infarction vetricular remodeling,” Reviews in Cardiovascular Medicine, vol. 4, supplement 3, pp. S3–S12, 2003. View at Google Scholar · View at Scopus
  4. X. Zeng, H. He, J. Yang et al., “Temporal effect of Guanxin No. 2 on cardiac function, blood viscosity and angiogenesis in rats after long-term occlusion of the left anterior descending coronary artery,” Journal of Ethnopharmacology, vol. 118, no. 3, pp. 485–494, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. P. L. Bu, X. Q. Zhao, L. L. Wang, Y. X. Zhao, C. B. Li, and Y. Zhang, “Tong-xin-luo capsule inhibits left venticular remodeling in spontaneously hypertensive rats by enhancing PPAR-γ expression and suppressing NF-κB activity,” Chinese Medical Journal, vol. 121, no. 2, pp. 147–154, 2008. View at Google Scholar · View at Scopus
  6. G. Cai, B. Liu, W. Liu et al., “Buyang Huanwu Decoction can improve recovery of neurological function, reduce infarction volume, stimulate neural proliferation and modulate VEGF and Flk1 expressions in transient focal cerebral ischaemic rat brains,” Journal of Ethnopharmacology, vol. 113, no. 2, pp. 292–299, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Wang and D. M. Jiang, “Neuroprotective effect of Buyang Huanwu Decoction on spinal ischemia/reperfusion injury in rats,” Journal of Ethnopharmacology, vol. 124, no. 2, pp. 219–223, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. X. M. Li, X. C. Bai, L. N. Qin, H. Huang, Z. J. Xiao, and T. M. Gao, “Neuroprotective effects of Buyang Huanwu Decoction on neuronal injury in hippocampus after transient forebrain ischemia in rats,” Neuroscience Letters, vol. 346, no. 1-2, pp. 29–32, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Zhang, W. R. Wang, R. Lin et al., “Buyang Huanwu decoction ameliorates coronary heart disease with Qi deficiency and blood stasis syndrome by reducing CRP and CD40 in rats,” Journal of Ethnopharmacology, vol. 130, no. 1, pp. 98–102, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Yang, Z. Fang, Y. Liu et al., “Protective effects of Chinese traditional medicine Buyang Huanwu Decoction on myocardial injury,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 930324, 7 pages, 2011. View at Publisher · View at Google Scholar
  11. D. Xu and F. Zhang, “Clinical study on inproving effect with Buyang Huanwu decoction (BYHWD) on cardiac remodeling and heart function in patients after myocardial infarction,” Integrated Traditional Chinese and Western Medicine In Practice of Critical Care Medicine, vol. 8, pp. 298–300, 2001. View at Google Scholar
  12. Q. Zheng and Y. Zhou, “Effect of Buyang Huanwu Decoction on improving left ventricular function in rats with ventricular remodeling after myocardial infarction,” Journal of New Chinese Medicine, vol. 42, pp. 109–111, 2010. View at Google Scholar
  13. H. Jia, Y. Zhang, L. Li et al., “Dingxin recipe prevents ischemia/reperfusion-induced arrhythmias via up-regulating prohibitin and suppressing inflammatory responses,” Chinese Journal of Integrative Medicine, vol. 18, no. 2, pp. 120–129, 2012. View at Google Scholar
  14. J. Boissiere, V. Eder, M. C. Machet, D. Courteix, and P. Bonnet, “Moderate exercise training does not worsen left ventricle remodeling and function in untreated severe hypertensive rats,” Journal of Applied Physiology, vol. 104, no. 2, pp. 321–327, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. X. G. Sun, X. L. Zhong, Z. F. Liu et al., “Proteomic analysis of chronic restraint stress-induced Gan-stagnancy syndrome in rats,” Chinese Journal of Integrative Medicine, vol. 16, no. 6, pp. 510–517, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. H. B. Cai, X. G. Sun, Z. F. Liu et al., “Effects of dahuangzhechong pills on cytokines and mitogen activated protein kinase activation in rats with hepatic fibrosis,” Journal of Ethnopharmacology, vol. 132, no. 1, pp. 157–164, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. Q. R. Wang, X. Q. Yao, G. Wen et al., “Apigenin suppresses the growth of colorectal cancer xenografts via phosphorylation and up-regulated FADD expression,” Oncology Letters, vol. 2, no. 1, pp. 43–47, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Jain, R. Liao, S. Ngoy, P. Whittaker, C. S. Apstein, and F. R. Eberli, “Angiotensin II receptor blockade attenuates the deleterious effects of exercise training on post-MI ventricular remodelling in rats,” Cardiovascular Research, vol. 46, no. 1, pp. 66–72, 2000. View at Publisher · View at Google Scholar · View at Scopus
  19. S. W. M. John, J. H. Krege, P. M. Oliver et al., “Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension,” Science, vol. 267, no. 5198, pp. 679–681, 1995. View at Google Scholar · View at Scopus
  20. M. E. Steinhelper, K. L. Cochrane, and L. J. Field, “Hypotension in transgenic mice expressing atrial natriuretic factor fusion genes,” Hypertension, vol. 16, no. 3, pp. 301–307, 1990. View at Google Scholar · View at Scopus
  21. J. C. Burnett, P. C. Kao, D. C. Hu et al., “Atrial natriuretic peptide elevation in congestive heart failure in the human,” Science, vol. 231, no. 4742, pp. 1145–1147, 1986. View at Google Scholar · View at Scopus
  22. T. Nishikimi, N. Maeda, and H. Matsuoka, “The role of natriuretic peptides in cardioprotection,” Cardiovascular Research, vol. 69, no. 2, pp. 318–328, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Qian, X. Ren, X. Wang et al., “Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death,” Circulation Research, vol. 105, no. 12, pp. 1223–1231, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Nicolaou, R. Knöll, K. Haghighi et al., “Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects,” The Journal of Biological Chemistry, vol. 283, no. 48, pp. 33465–33471, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Nagy, G. Malik, A. B. Fisher, and D. K. Das, “Targeted disruption of peroxiredoxin 6 gene renders the heart vulnerable to ischemia-reperfusion injury,” American Journal of Physiology, vol. 291, no. 6, pp. H2636–H2640, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. X. G. Sun, X. Q. Fu, H. B. Cai et al., “Proteomic analysis of protective effects of polysaccharides from Salvia miltiorrhiza against immunological liver injury in mice,” Phytotherapy Research, vol. 25, pp. 1087–1094, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. C. F. Wu, N. H. Bishopric, and R. E. Pratt, “Atrial natriuretic peptide induces apoptosis in neonatal rat cardiac myocytes,” The Journal of Biological Chemistry, vol. 272, no. 23, pp. 14860–14866, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Ma and Z. Z. Guan, “Effect of astragalus injection on left ventricular remodeling and apoptotic gene caspase-3 in rats after myocardial infarction,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 25, no. 7, pp. 646–649, 2005. View at Google Scholar · View at Scopus
  29. Z. Zhao, W. Wang, F. Wang et al., “Effects of astragaloside IV on heart failure in rats,” Chinese Medicine, vol. 4, article 6, 2009. View at Publisher · View at Google Scholar
  30. X. Shen, X. Y. Mo, and X. Y. Du, “The protective effect of total paeony glycoside on apoptosis in myocardial ischemic rats,” Chinese Pharmacological Bulletin, vol. 23, no. 10, pp. 1300–1305, 2007. View at Google Scholar · View at Scopus
  31. H. J. Shangguan, J. Xu, H. S. Guan, and Y. F. Zhao, “Effects of radix angelicae sinensis on myocardial apoptosis and ventricular remolding after myocardial infarction,” Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care, vol. 15, pp. 39–45, 2008. View at Google Scholar
  32. Y. L. Lin, G. J. Wang, C. L. Huang et al., “Ligusticum chuanxiong as a potential neuroprotectant for preventing serum deprivation-induced apoptosis in rat pheochromocytoma cells: functional roles of mitogen-activated protein kinases,” Journal of Ethnopharmacology, vol. 122, no. 3, pp. 417–423, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. D. Li, Y. H. Ma, J. X. Zhao, and X. K. Zhao, “Protection of ultra-filtration extract from Danggui Buxue Decoction on oxidative damage in cardiomyocytes of neonatal rats and its mechanism,” Chinese Journal of Integrative Medicine, vol. 17, pp. 854–859, 2011. View at Google Scholar
  34. L. Liu, J. A. Duan, Y. Tang et al., “Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation,” Journal of Ethnopharmacology, vol. 139, pp. 381–387, 2012. View at Google Scholar
  35. M. Kasim, A. A. Kiat, M. S. Rohman, Y. Hanifah, and H. Kiat, “Improved myocardial perfusion in stable angina pectoris by oral lumbrokinase: a pilot study,” Journal of Alternative and Complementary Medicine, vol. 15, no. 5, pp. 539–544, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. C. M. Hwang, D. I. Kim, S. H. Huh et al., “In vivo evaluation of lumbrokinase, a fibrinolytic enzyme extracted from Lumbricus rubellus, in a prosthetic vascular graft,” Journal of Cardiovascular Surgery, vol. 43, no. 6, pp. 891–894, 2002. View at Google Scholar · View at Scopus
  37. G. C. Fan, X. Ren, J. Qian et al., “Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury,” Circulation, vol. 111, no. 14, pp. 1792–1799, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. E. Hoehhauser, S. Kivity, D. Offen et al., “Bax ablation protects against myocardial ischemiareperfusion injury in transgenic mice,” American Journal of Physiology, vol. 284, no. 6, pp. H2351–H2359, 2003. View at Google Scholar · View at Scopus
  39. W. Zhao, G. C. Fan, Z. G. Zhang, A. Bandyopadhyay, X. Zhou, and E. G. Kranias, “Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis,” Basic Research in Cardiology, vol. 104, no. 4, pp. 377–389, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. A. B. Fisher, “Peroxiredoxin 6: a bifunctional enzyme with glutathione peroxidase and phospholipase a2 activities,” Antioxidants & Redox Signaling, vol. 15, no. 3, pp. 831–844, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. Y. C. Lien, S. I. Feinstein, C. Dodia, and A. B. Fisher, “The roles of peroxidase and phospholipase A2 activities of peroxiredoxin 6 in protecting pulmonary microvascular endothelial cells against peroxidative stress,” Antioxidants & Redox Signaling, vol. 16, pp. 440–451, 2012. View at Google Scholar
  42. A. G. Cox, K. K. Brown, E. S. J. Arner, and M. B. Hampton, “The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation,” Biochemical Pharmacology, vol. 76, no. 9, pp. 1097–1109, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. D. D. Rowe, C. C. Leonardo, J. A. Recio, L. A. Collier, A. E. Willing, and K. R. Pennypacker, “Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction,” The Journal of Biological Chemistry, vol. 287, pp. 4177–4187, 2012. View at Google Scholar
  44. J. N. Cohn, R. Ferrari, and N. Sharpe, “Cardiac remodeling-concepts and clinical implications: a consensus paper from an International Forum on Cardiac Remodeling,” Journal of the American College of Cardiology, vol. 35, no. 3, pp. 569–582, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. N. Guttenplan, C. Lee, and W. H. Frishman, “Inhibition of myocardial apoptosis as a therapeutic target in cardiovascular disease prevention: focus on caspase inhibition,” Heart Disease, vol. 3, no. 5, pp. 313–318, 2001. View at Google Scholar · View at Scopus