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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 395912, 8 pages
Research Article

Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases

1Key Laboratory of Contraceptives and Devices Research (NPFPC), Shanghai Engineer and Technology Research Center of Reproductive Health Drug and Devices, Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China
2Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
3Pharmacy College, Jinan University, Guangzhou 510632, China
4Occupational and Environmental Health Department, Dalian Medical University, Dalian 116044, China

Received 19 July 2012; Accepted 14 September 2012

Academic Editor: Gerhard Litscher

Copyright © 2012 Yun-Feng Cao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • Zhen Li, Florence Shin Gee Cheung, Jian Zheng, Ting Chan, Ling Zhu, and Fanfan Zhou, “Interaction of the Bioactive Flavonol, Icariin, with the Essential Human Solute Carrier Transporters,” Journal of Biochemical and Molecular Toxicology, vol. 28, no. 2, pp. 91–97, 2013. View at Publisher · View at Google Scholar
  • Shang-Fu Xu, Tao Jin, Yuan-Fu Lu, Li-Sheng Li, Jie Liu, and Jing-Shan Shi, “Effect of Icariin on UDP-Glucuronosyltransferases in Mouse Liver,” Planta Medica, vol. 80, no. 5, pp. 387–392, 2014. View at Publisher · View at Google Scholar
  • Lina Shan, Shuman Yang, Gang Zhang, Dun Zhou, Zhenyu Qiu, Lei Tian, Hongxia Yuan, Yujun Feng, and Xianbao Shi, “Comparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP-Glucuronosyltransferases,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, pp. 1–6, 2014. View at Publisher · View at Google Scholar
  • Nan Zhang, Yong Liu, and Hyunyoung Jeong, “Drug-Drug Interaction Potentials of Tyrosine Kinase Inhibitors via Inhibition of UDP-Glucuronosyltransferases,” Scientific Reports, vol. 5, 2015. View at Publisher · View at Google Scholar
  • Chenrui Li, Qiang Li, Qibing Mei, and Tingli Lu, “Pharmacology effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii,” Life Sciences, 2015. View at Publisher · View at Google Scholar
  • Da Cheng Hao, and Ling Yang, “Drug metabolism and disposition diversity of Ranunculales phytometabolites: a systems perspective,” Expert Opinion on Drug Metabolism & Toxicology, pp. 1–19, 2016. View at Publisher · View at Google Scholar
  • Zhijie Cui, Zhen Sheng, Xinmiao Yan, Zhiwei Cao, and Kailin Tang, “In Silico Insight into Potential Anti-Alzheimer’s Disease Mechanisms of Icariin,” International Journal of Molecular Sciences, vol. 17, no. 1, pp. 113, 2016. View at Publisher · View at Google Scholar