Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases

Table 1

The IC₅₀ values for the inhibition of icariin and its intestinal metabolites on UGT activities^a.

IC50(𝜇M)	Icariin	Icariside I	Icariside II	Icaritin
UGT1A1	>100	>100	>100	>100
UGT1A3	12.4±0.1	>100	>100	>100
UGT1A4	42.8±2.4	>100	2.9±0.1	>100
UGT1A6	>100	>100	>100	>100
UGT1A7	>100	>100	2.8 ± 0.10	0.3 ± 0.0
UGT1A8	>100	>100	>100	>100
UGT1A9	>100	>100	2.4 ± 0.1	1.5 ± 0.1
UGT1A10	>100	>100	>100	>100
UGT2B4	>100	>100	>100	>100
UGT2B7	>100	>100	12.5 ± 0.1	>100
UGT2B15	>100	>100	>100	>100
UGT2B17	>100	>100	>100	>100

^aData were showed as mean ± SD. All experiments were separately performed in duplicate for three times.