Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells
Figure 1
Demethoxycurcumin (DMC) mediates the survival of GBM 8401 cells and thus inhibits their proliferation. (a) In vitro study was initiated by treating each of the GBM 8401 cells to increasing doses of DMC (0, 12.5, 25, 50 and 100 μM) for 24 or 48 hours. The survival of these DMC-treated cancer cells was then measured by MTT method. Results were expressed as a percentage of control, which was considered as 100%. All data were reported as the means (±SEM) of at least three separate experiments. Statistical analysis was via t-test, with the significant differences determined at the level of * versus control group (DMC 0 μM). (b) The morphology of the human GBM 8401 cells after the treatment with DMC (25 μM) for 4 and 24 hours changed with the cells being distorted and suspended in the medium.
