Gastroprotective Activity of Polygonum chinense Aqueous Leaf Extract on Ethanol-Induced Hemorrhagic Mucosal Lesions in Rats
Figure 1
Macroscopic appearance of gastric mucosal lesions of the rats in different groups. (a) Rats in the normal control group showed intact gastric mucosa. (b) The ulcer control group (pretreated with 5 mL/kg absolute alcohol) showed severe injuries to the gastric mucosa (white arrow). Absolute ethanol imposed extensive hemorrhagic necrosis to gastric mucosa. (c) The reference group (omeprazole 20 mg/kg) showed milder injuries to the gastric mucosa (white arrow) compared with the ulcer control rats. (d) Rat pre-treated with P. chinense (62.50 mg/kg) showed moderate injuries on the gastric mucosa (white arrow). (e) Pre-treated with 125 mg/kg of P. chinense extract suppressed lesions to a mild-moderate condition (white arrow). (f) Mild injuries of the gastric mucosa were found in those rats pre-treated with 250 mg/kg of P. chinense extract. (g) Pre-treatment with 500 mg/kg of the extract protected injuries at a mild condition and flattened the gastric mucosa observed (black arrow).
