Gastroprotective Activity of Polygonum chinense Aqueous Leaf Extract on Ethanol-Induced Hemorrhagic Mucosal Lesions in Rats
Figure 2
Histology evaluation of gastric mucosal lesions of the rats in different groups (H&E staining 10x). (a) Rats in the normal control group showed intact gastric mucosa. (b) The ulcer control group (pre-treated with 5 mL/kg absolute alcohol) showed severe disruption on the epithelium. The necrotic lesions penetrated deeply into mucosa (white arrow). Also, extensive edema and leucocyte infiltration of submucosal layer were seen (black arrow). (c) The reference group (omeprazole 20 mg/kg) showed a mild disruption of the epithelium with edema and leucocyte infiltration of submucosal layer. (d) Rat pre-treated with P. chinense (62.50 mg/kg) showed a moderate disruption of epithelium with edema and leucocytes infiltration of submucosal layer. (e) Pre-treated with 125 mg/kg of P. chinense extract suppressed disruption of surface epithelium with edema and leucocyte infiltration of submucosal layer to a mild-moderate condition. (f) Mild disruption of the epithelium was found in those rats pre-treated with 250 mg/kg of P. chinense extract. (g) Pre-treatment with 500 mg/kg of the extract protected the epithelium from disruption at a mild condition along with a mild edema and leucocytes infiltration of the submucosal layer.
