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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 404529, 6 pages
Research Article

The Metabolism of Baicalin in Rat and the Biological Activities of the Metabolites

1Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Liaoing 110016, China
2Key Laboratory of Marine Drugs, Chinese Ministry of Education and School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

Received 27 December 2011; Revised 15 February 2012; Accepted 6 March 2012

Academic Editor: Shuang-En Chuang

Copyright © 2012 Yi Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Baicalin is one of the major bioactive constituents of Scutellariae Radix, but the biotransformation of it is poorly understood. In this paper, the metabolism of baicalin in rat was studied. Nine metabolites including one new compound were isolated and identified structurally. The plausible scheme for the biotransformation pathways of baicalin in the rats was deduced. And the main metabolites were evaluated for their antioxidation and anti-inflammation biological activities for the first time.