Oroxylin A, but Not Vasopressin, Ameliorates Cardiac Dysfunction of Endotoxemic Rats
Figure 6
Effects of endothelium-denudation on CPP induced by 5-HT and Oro-A in isolated hearts from normal control rats. A representative tracing in (a) shows that 5-HT (1 μM) decreased CPP. After intravascular infusion with saponin (50 μg/mL) for 15 min, the decreased CPP induced by Oro-A (10 μM) was not affected, while that induced by 5-HT was blocked and converted to an increase. These effects of Oro-A (10 μM) and 5-HT (1 μM) on CPP (percentage of 100 μM SNP-induced) before (solid bar) and after (open bar) saponin are summarized in (b). Values are mean ± SEM (). * versus presaponin; NS (not significant, ). 5-HT (5-hydroxytryptamine); SNP (sodium nitroprusside).
