Oroxylin A, but Not Vasopressin, Ameliorates Cardiac Dysfunction of Endotoxemic Rats
Table 1
Changes of body temperature and hemodynamic parameters in 5 hr and 16 hr post-LPS (10 mg/kg, i.p.) rats.
Preparations
Parameters
Control
5 hrs
16 hrs
Whole animals
n
22
23
18
BT (°C)
36.9 ± 0.1
39.0 ± 0.1*
38.2 ± 0.1*#
MAP (mmHg)
111 ± 2.1
112 ± 2.2
72 ± 2.3*#
HR (bpm)
336 ± 9.9
435 ± 7.5*
454 ± 5.2*
Isolated heart (constant pressure)
n
6
6
6
CF (mL/min)
13 ± 0.1
7.1 ± 0.5*
15.6 ± 0.7*#
LVDP (mmHg)
80.8 ± 4.0
42.9 ± 4.8*
45.2 ± 4.1*
HR (bpm)
292.1 ± 6.2
277.5 ± 2.0
338.4 ± 8.6*#
RPP (mmHg·bpm)
23321 ± 755
10836 ± 912*
13528 ± 560*
Isolated heart (constant flow)
n
6
6
6
CPP (mL/min)
94.1 ± 0.6
122.2 ± 3.6*
53.8 ± 3.0*#
LVDP (mmHg)
89.9 ± 3.1
45.0 ± 2.2*
41.8 ± 1.9*
HR (bpm)
299.4 ± 7.1
317.5 ± 7.9
312.5 ± 8.9
RPP (mmHg·bpm)
26837 ± 841
14181 ± 976*
12763 ± 596*
Isolated right atrium
n
5
6
6
Force (mg/mg)
12.5 ± 1.0
8.0 ± 1.0*
6.2 ± 0.6*
Rate (bpm)1
321.1 ± 6.8
348.1 ± 7.9*
355.4 ± 13.2*
Isolated right ventricle
n
5
5
N/P
Force (mg/mg)
13.9 ± 2.4
6.3 ± 0.3*
N/P
Rate (bpm)2
120.0 ± 0.0
120.0 ± 0.0
N/P
Values are mean ± SEM. *P < 0.05 versus control group, #P <0.05 versus 5 hr LPS group. 1The spontaneous beating rate of the atrium was considered as sinoatrial electrical activity. 2The ventricular rate was triggered by electric stimulation with a frequency of 2 Hz. BT (body temperature); MAP (mean arterial pressure); HR (heart rate); CF (coronary flow); CPP (coronary perfusion pressure); LVDP (left ventricular developed pressure); RPP (rate-pressure product); bpm (beats per min); N/P (not performed).
