Research Article

In Vitro and In Vivo Genotoxicity Assessment of Aristolochia manshuriensis Kom.

Figure 4

Effect of Aristolochiae manshuriensis Kom. (AMK, 0, 1250, 2500, and 5000 mg/kg body weight, oral administration) on the incidence (%) of micronucleated polychromatic erythrocyte (MNPCE, histogram bar, left Y-axis) and the PCE/NCE (polychromatic/normochromatic erythrocyte) ratio (curve with dot, right Y-axis) in preliminary ((a), ) and main study ((b), ). (−), vehicle control; (+), positive control (mitomycin C, MMC, 2 mg/kg). Asterisks denote statistically differences (* , ** ).