Randomised, Double Blind, Placebo-Controlled Trial of Echinacea Supplementation in Air Travellers

Table 1

Alkylamide content per Echinacea tablet used as trial medication.

Alkylamide name	MW	Structure	mg/tablet^a
(2E/Z,4Z/E)-N-(2-Methylpropyl)undeca-2,4-diene-8,10-diynamide	229	Diene	0.247
(2E,4Z)-N-(2-Methylpropyl)dodeca-2,4-diene-8,10-diynamide	243	Diene	0.505
(2E,4E,8Z/E,10Z/E)-N-(2-Methylpropyl)dodeca-2,4,8,10-tetraenamide	247	Diene	1.504
(2E,4E,8Z)-N-(2-Methylpropyl)dodeca-2,4,8-trienamide	249	Diene	0.078
(2E,4E)-N-(2-Methylpropyl)dodeca-2,4-dienamide	251	Diene	0.166
(2E,4Z)-N-(2-Methylbutyl)dodeca-2,4-diene-8,10-diynamide	257	Diene	0.130
(2E/Z)-N-(2-Methylpropyl)undec-2-ene-8,10-diynamide	231	Monoene	0.699
(2E)-N-(2-Methylpropyl)dodec-2-ene-8,10-diynamide	245	Monoene	0.452
(2E,7Z)-N-(2-Methylpropyl)trideca-2,7-diene-10,12-diynamide	257	Monoene	0.081
(2E0-N-(2-Methylbutyl)dodec-2-ene-8,10-diynamide	259	Monoene	0.186
(2E,9Z)-N-(2-Methylpropyl)pentadeca-2,9-diene-12,14-diynamide	285	Monoene	0.330
(2E,9Z)-N-(2-Methylpropyl)hexadeca-2,9-diene-12,14-diynamide	299	Monoene	0.041
Total			4.419

^a Alkylamide concentrations were determined by liquid chromatography mass spectrometry using a Shimadzu HPLC system coupled to a Shimadzu 2010EV single quadrupole mass spectrometer operating with an APCI interface as described for a previous batch [25].