Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 418679, 9 pages
http://dx.doi.org/10.1155/2012/418679
Research Article

Plectranthus amboinicus and Centella asiatica Cream for the Treatment of Diabetic Foot Ulcers

1Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan
2Department of Surgery, National Taiwan University College of Medicine, No. 1, Section 1, Jen-Ai Road, Taipei 10051, Taiwan
3Oneness Biotech Co., Ltd., 7F-1, No. 3-1, Yuan Qu Street, Nangang District, Taipei 115, Taiwan

Received 17 February 2012; Accepted 5 April 2012

Academic Editor: Esra K├╝peli Akkol

Copyright © 2012 Yuan-Sung Kuo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.